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血色素沉着症与献血

Hemochromatosis and blood donation.

作者信息

Braseth Turid Aarhus, Hervig Tor, Rosvik Anne Synnove

机构信息

Faculty of Engineering and Business Administration, Department of Biomedical Laboratory Sciences and Chemical Engineering, Bergen University College, pb 7030, 5020 Bergen, Norway; Western Norway University of Applied Sciences, Postbox 7030, 5020 Bergen, Norway.

Institute of Clinical Sciences, University of Bergen, 5021 Bergen, Norway; Department of Immunology and transfusion medicine, Haukeland University Hospital, 5021 Bergen, Norway.

出版信息

Transfus Apher Sci. 2017 Jun;56(3):485-489. doi: 10.1016/j.transci.2017.05.012. Epub 2017 May 18.

DOI:10.1016/j.transci.2017.05.012
PMID:28610845
Abstract

The voluntary, unpaid, altruistic blood donor is a cornerstone of current transfusion medicine. The complexity of medical and ethical issues related to blood donation and hemochromatosis has led to a large number of studies related to the safety of the hemochromatosis donor and the quality of the blood components produced from these donations. The issue of accepting persons with HC as blood donors is diverting, both in Europe and worldwide and without joint guidelines. A questionnaire-based study was performed and mailed to all 25 blood bank leaders in Norway. Descriptive analysis was used to evaluate the data. Eight of 22 blood banks strictly followed national guidelines concerning persons with hemochromatosis. Other blood banks make local adjustments. 16 of 22 responding blood banks accept hemochromatosis donors and five do not, and one answered partly yes. The reasons the blood bank leaders supported the acceptance of hemochromatosis donors differ. Based on published papers and the present questionnaire, we believe that a clear definition of the "hemochromatosis donor" and guidelines with more detailed information on an acceptable donation regime would be important to overcome the weak points in blood donor eligibility criteria.

摘要

自愿无偿献血者是当前输血医学的基石。与献血和血色素沉着症相关的医学和伦理问题的复杂性导致了大量关于血色素沉着症献血者安全性以及这些献血所产生血液成分质量的研究。在欧洲乃至全球,接受血色素沉着症患者作为献血者的问题存在分歧,且没有统一的指导方针。我们开展了一项基于问卷调查的研究,并将问卷邮寄给了挪威所有25位血库负责人。采用描述性分析来评估数据。22家血库中有8家严格遵循关于血色素沉着症患者的国家指导方针。其他血库则进行了局部调整。22家回复的血库中,16家接受血色素沉着症献血者,5家不接受,1家部分接受。血库负责人支持接受血色素沉着症献血者的原因各不相同。基于已发表的论文和本次问卷调查,我们认为明确“血色素沉着症献血者”的定义以及制定关于可接受献血制度的更详细信息的指导方针,对于克服献血者资格标准中的薄弱环节至关重要。

相似文献

1
Hemochromatosis and blood donation.血色素沉着症与献血
Transfus Apher Sci. 2017 Jun;56(3):485-489. doi: 10.1016/j.transci.2017.05.012. Epub 2017 May 18.
2
Eligibility and exclusion of hemochromatosis patients as voluntary blood donors.血色素沉着症患者作为自愿献血者的资格与排除标准。
Can J Gastroenterol. 1998 Jan-Feb;12(1):61-3. doi: 10.1155/1998/590428.
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Demanding pure motives for donation: the moral acceptability of blood donations by haemochromatosis patients.苛求献血的纯粹动机:血色素沉着症患者献血的道德可接受性
J Med Ethics. 2005 Feb;31(2):69-72. doi: 10.1136/jme.2002.001271.
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The revision of the European blood directives: A major challenge for transfusion medicine.欧洲血液指令的修订:输血医学面临的一项重大挑战。
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Prevalence, donation practices, and risk assessment of blood donors with hemochromatosis.血色素沉着症献血者的患病率、献血行为及风险评估
JAMA. 2001 Sep 26;286(12):1475-81. doi: 10.1001/jama.286.12.1475.
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Hemochromatosis patients as voluntary blood donors.血色素沉着症患者作为自愿献血者。
Can J Gastroenterol. 2004 Jun;18(6):393-6. doi: 10.1155/2004/767529.
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Worldwide policies on haemochromatosis and blood donation: a survey among blood services.全球范围内的血色素沉着病和献血政策:血液服务机构的调查。
Vox Sang. 2013 Aug;105(2):121-8. doi: 10.1111/vox.12038. Epub 2013 May 11.
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Is the unpaid/paid donation debate for better or for worse?--advantages of unpaid donations.
Blood Coagul Fibrinolysis. 1994 Dec;5 Suppl 4:S27-8. doi: 10.1097/00001721-199412004-00007.
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Cost-effectiveness of FDA variance for blood collection from individuals with hereditary hemochromatosis at a 398-bed hospital-based donor center.在一家拥有398张床位的医院供血中心,针对遗传性血色素沉着症患者采血的美国食品药品监督管理局(FDA)差异的成本效益分析
Immunohematology. 2009;25(4):170-3.
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Blood donors and factors impacting the blood donation decision: motives for donating blood in Turkish sample.献血者及影响献血决策的因素:土耳其样本中献血的动机
Transfus Apher Sci. 2013 Dec;49(3):468-73. doi: 10.1016/j.transci.2013.04.044. Epub 2013 May 23.

引用本文的文献

1
Population Screening for Hereditary Haemochromatosis-Should It Be Carried Out, and If So, How?人群遗传性血色素沉着症筛查——是否应该开展,如果开展,应如何进行?
Genes (Basel). 2024 Jul 23;15(8):967. doi: 10.3390/genes15080967.
2
Blood donation for iron removal in individuals with HFE mutations: study of efficacy and safety and short review on hemochromatosis and blood donation.针对具有HFE基因突变个体进行的用于铁清除的献血:疗效与安全性研究以及关于血色素沉着症和献血的简短综述
Front Med (Lausanne). 2024 Mar 19;11:1362941. doi: 10.3389/fmed.2024.1362941. eCollection 2024.