Morrison A S
J Natl Cancer Inst. 1979 Jun;62(6):1397-9.
Current daily use of artificial sweeteners (AS) and diet drinks was evaluated for 1,862 patients hospitalized for cancer and for 10,874 "control" patients hospitalized for other conditions believed not to be associated with use of these substances. The data were derived from an ongoing survey in seven countries. For cancer of most sites, the age-standardized proportion of users of AS was somewhat less than that for controls. A greater proportion of users among cancer patients than among controls was noted only for cancer of the stomach among women. Little information on urinary tract cancer was available; there were no users of AS among 13 patients with cancer of the bladder, 5 with cancer of the renal pelvis, and 2 with cancer of the ureter. There were 455 cancer patients known to have been interviewed during their initial hospitalization for the disease. Based on these cases, an age-sex-country-standardized estimate of cancer incidence for users of AS, relative to nonusers, was 1.0. Only a very small proportion of patients reported daily use of diet drinks, and the proportion of users did not differ substantially between cancer patients and controls. The present data provide virtually no support for an overall positive association of AS with cancer.
对1862名因癌症住院的患者以及10874名因其他被认为与这些物质使用无关的疾病住院的“对照”患者，评估了人工甜味剂（AS）和低糖饮料的当前日常使用情况。数据来自七个国家正在进行的一项调查。对于大多数部位的癌症，AS使用者的年龄标准化比例略低于对照组。仅在女性胃癌患者中，癌症患者中使用者的比例高于对照组。关于泌尿系统癌症的信息很少；13名膀胱癌患者、5名肾盂癌患者和2名输尿管癌患者中均无AS使用者。有455名癌症患者在初次因该疾病住院期间接受了访谈。基于这些病例，AS使用者相对于非使用者的年龄、性别、国家标准化癌症发病率估计值为1.0。只有极少数患者报告日常饮用低糖饮料，癌症患者和对照组中使用者的比例没有显著差异。目前的数据几乎不支持AS与癌症之间存在总体正相关。
