Shift of circadian metabolic rhythm in BFO osteosarcoma-bearing mice.

The diurnal rhythms of the contents of serum corticosterone and liver glycogen and the activity of liver tyrosine aminotransferase gradually shifted forward in C3H/He mice bearing BFO osteosarcoma. The production of alkaline phosphatase by the tumor showed a circadian rhythm. The eating behavior of tumor-bearing mice seemed to be responsible for their change in circadian rhythm.