Cappellini Maria Domenica, Comin-Colet Josep, de Francisco Angel, Dignass Axel, Doehner Wolfram, Lam Carolyn S, Macdougall Iain C, Rogler Gerhard, Camaschella Clara, Kadir Rezan, Kassebaum Nicholas J, Spahn Donat R, Taher Ali T, Musallam Khaled M
Rare Diseases Centre, Department of Medicine and Medical Specialties, Fondazione IRCCS Ca'Granda-Ospedale Maggiore Policlinico, Milan, Italy.
Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy.
Am J Hematol. 2017 Oct;92(10):1068-1078. doi: 10.1002/ajh.24820. Epub 2017 Jul 7.
Iron deficiency, even in the absence of anemia, can be debilitating, and exacerbate any underlying chronic disease, leading to increased morbidity and mortality. Iron deficiency is frequently concomitant with chronic inflammatory disease; however, iron deficiency treatment is often overlooked, partially due to the heterogeneity among clinical practice guidelines. In the absence of consistent guidance across chronic heart failure, chronic kidney disease and inflammatory bowel disease, we provide practical recommendations for iron deficiency to treating physicians: definition, diagnosis, and disease-specific diagnostic algorithms. These recommendations should facilitate appropriate diagnosis and treatment of iron deficiency to improve quality of life and clinical outcomes.
缺铁即使在没有贫血的情况下也可能使人虚弱，并加重任何潜在的慢性疾病，导致发病率和死亡率增加。缺铁常与慢性炎症性疾病同时存在；然而，缺铁的治疗常常被忽视，部分原因是临床实践指南之间存在异质性。在慢性心力衰竭、慢性肾病和炎症性肠病缺乏一致指导的情况下，我们为治疗医生提供关于缺铁的实用建议：定义、诊断以及针对特定疾病的诊断算法。这些建议应有助于缺铁的恰当诊断和治疗，以改善生活质量和临床结局。
