Tang Su-Min, Shen Chao-Yong, Yin Yuan, Yin Xiao-Nan, Cai Zhao-Lun, Chen Zhi-Xin, Zhang Bo
Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2017 Mar;48(2):234-238.
To determine the association of FAP expression with the prognosis of gastric stromal tumors (GSTs).
Paraffin-embedded GSTs samples were collected from January 2010 to December 2013 in the department of pathology of our hospital. FAP expression was examined by immunohistochemistry staining. Its correlations with clinical pathological characteristics and prognosis of GSTs were analyzed.
A total of 98 cases were included in this study. FAP was expressed in the cytoplasm of GSTs cells, with a positive rate of 42.9%. No FAP expression was found in normal gastric tissues. No differences of FAP expression were found in patients with different gender, age and tumor mitotic counts ( >0.05). Tumor diameter and risk classification were associated with FAP expression ( <0.05). Higher levels of FAP expression were found in larger and higher risk tumors. No significant correlations between FAP expression and routine immunohistochemical markers were found. Log-rank univariate survival analysis showed that mitotic counts, tumor size, postoperative IM and FAP expression were associated with recurrence free survival of GSTs patients with intermediate-high risks ( <0.05). Cox multivariate survival analysis showed that mitotic counts, tumor size, postoperative IM and FAP were independent predictors for the prognosis of GSTs patients with intermediate-high risks ( <0.05).
FAP is expressed in the cytoplasm of gastric GIST cells, but not in normal gastric tissues. FAP is a predictor for the prognosis of GSTs patients with intermediate-high risks.
确定FAP表达与胃间质瘤（GSTs）预后的相关性。
收集2010年1月至2013年12月我院病理科石蜡包埋的GSTs样本。采用免疫组织化学染色检测FAP表达。分析其与GSTs临床病理特征及预后的相关性。
本研究共纳入98例病例。FAP在GSTs细胞胞质中表达，阳性率为42.9%。正常胃组织中未发现FAP表达。不同性别、年龄及肿瘤有丝分裂计数（>0.05）的患者FAP表达无差异。肿瘤直径和风险分类与FAP表达相关（<0.05）。在较大和较高风险的肿瘤中发现FAP表达水平较高。FAP表达与常规免疫组化标志物之间无显著相关性。Log-rank单因素生存分析显示，有丝分裂计数、肿瘤大小、术后伊马替尼（IM）治疗及FAP表达与中高危GSTs患者的无复发生存相关（<0.05）。Cox多因素生存分析显示，有丝分裂计数、肿瘤大小、术后IM治疗及FAP是中高危GSTs患者预后的独立预测因素（<0.05）。
FAP在胃GIST细胞胞质中表达，但在正常胃组织中不表达。FAP是中高危GSTs患者预后的预测指标。
