State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University , Nanjing 210093, China.
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry , Shanghai 200032, China.
Org Lett. 2017 Jul 7;19(13):3430-3433. doi: 10.1021/acs.orglett.7b01391. Epub 2017 Jun 14.
A hydroacylation reaction of alkenes has been achieved employing readily available carboxylic acids as the acyl source and hydrosilanes as a hydrogen source via photoredox catalysis. The combination of both single electron transfer and hydrogen atom transfer steps has dramatically expanded new applications of carboxylic acids in organic synthesis. The protocol also features extremely mild conditions, broad substrate scope, and good functional group tolerance, affording a novel and convenient approach to hydroacylation of alkenes.
通过光氧化还原催化，利用易得的羧酸作为酰基源和硅烷作为氢源，实现了烯烃的氢酰化反应。单电子转移和氢原子转移步骤的结合极大地扩展了羧酸在有机合成中的新应用。该方案还具有非常温和的条件、广泛的底物范围和良好的官能团耐受性，为烯烃的氢酰化提供了一种新颖、方便的方法。
