Bornelöv Susanne, Seroussi Eyal, Yosefi Sara, Pendavis Ken, Burgess Shane C, Grabherr Manfred, Friedman-Einat Miriam, Andersson Leif
Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, SE-751 23, Sweden.
Present Address: Wellcome Trust Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, CB2 1QR, UK.
Genome Biol. 2017 Jun 14;18(1):112. doi: 10.1186/s13059-017-1231-1.
Through RNA-Seq analyses, we identified 137 genes that are missing in chicken, including the long-sought-after nephrin and tumor necrosis factor genes. These genes tended to cluster in GC-rich regions that have poor coverage in genome sequence databases. Hence, the occurrence of syntenic groups of vertebrate genes that have not been observed in Aves does not prove the evolutionary loss of such genes.Please see related Research article: http://dx.doi.org/10.1186/s13059-014-0565-1 and Please see response from Lovell et al: https://www.dx.doi.org/10.1186/s13059-017-1234-y.
通过RNA测序分析,我们鉴定出137个在鸡中缺失的基因,包括长期寻找的nephrin和肿瘤坏死因子基因。这些基因倾向于聚集在基因组序列数据库中覆盖度较差的富含GC的区域。因此,在鸟类中未观察到的脊椎动物基因同线群的出现并不能证明此类基因在进化过程中丢失。请参阅相关研究文章:http://dx.doi.org/10.1186/s13059-014-0565-1 ,并请参阅Lovell等人的回复:https://www.dx.doi.org/10.1186/s13059-017-1234-y 。