Department of Biomedical Engineering, Boston University, Boston, Massachusetts.
Department of Medicine, Respiratory Division, University of British Columbia, Vancouver, British Columbia, Canada.
Physiology (Bethesda). 2017 Jul;32(4):322-331. doi: 10.1152/physiol.00008.2017.
We relate changes of the airway wall to the response of the intact airway and the whole lung. We address how mechanical conditions and specific structural changes for an airway contribute to hyperresponsiveness resistant to deep inspiration. This review conveys that the origins of hyperresponsiveness do not devolve into an abnormality at single structural level but require examination of the complex interplay of all the parts.
我们将气道壁的变化与完整气道和整个肺的反应联系起来。我们探讨了气道的机械条件和特定结构变化如何导致对深呼吸有抵抗力的高反应性。这篇综述表明，高反应性的起源并非单一结构水平的异常，而是需要检查所有部分的复杂相互作用。
