Knutson Mitchell D
Food Science and Human Nutrition Department, University of Florida, Gainesville, Florida 32611-03170.
J Biol Chem. 2017 Aug 4;292(31):12735-12743. doi: 10.1074/jbc.R117.786632. Epub 2017 Jun 14.
Cellular iron homeostasis is maintained by iron and heme transport proteins that work in concert with ferrireductases, ferroxidases, and chaperones to direct the movement of iron into, within, and out of cells. Systemic iron homeostasis is regulated by the liver-derived peptide hormone, hepcidin. The interface between cellular and systemic iron homeostasis is readily observed in the highly dynamic iron handling of four main cell types: duodenal enterocytes, erythrocyte precursors, macrophages, and hepatocytes. This review provides an overview of how these cell types handle iron, highlighting how iron and heme transporters mediate the exchange and distribution of body iron in health and disease.
细胞铁稳态由铁和血红素转运蛋白维持，这些蛋白与铁还原酶、铁氧化酶和伴侣蛋白协同作用，以指导铁进出细胞以及在细胞内的移动。系统性铁稳态由肝脏衍生的肽激素铁调素调节。在四种主要细胞类型（十二指肠肠上皮细胞、红细胞前体、巨噬细胞和肝细胞）高度动态的铁处理过程中，很容易观察到细胞和系统性铁稳态之间的相互作用。本综述概述了这些细胞类型如何处理铁，重点介绍了铁和血红素转运蛋白在健康和疾病状态下如何介导体内铁的交换和分布。
