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Bupropion and Iron for Restless Leg Syndrome: Do They Have Efficacy Similar to Ropinirole?安非他酮与铁剂治疗不宁腿综合征：它们的疗效与罗匹尼罗相似吗？
Ann Indian Acad Neurol. 2017 Apr-Jun;20(2):166-167. doi: 10.4103/0972-2327.205775.
2
A double-blind, randomized, controlled trial to compare the efficacy and tolerability of fixed doses of ropinirole, bupropion, and iron in treatment of restless legs syndrome (Willis-Ekbom disease).一项双盲、随机、对照试验，比较固定剂量的罗匹尼罗、安非他酮和铁剂治疗不安腿综合征（ Willis-Ekbom病）的疗效和耐受性。
Ann Indian Acad Neurol. 2016 Oct-Dec;19(4):472-477. doi: 10.4103/0972-2327.194424.
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Ropinirole: new indication. Restless legs: disproportionate adverse effects.罗匹尼罗：新适应症。不宁腿：不良反应不成比例。
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4
Ropinirole treatment for restless legs syndrome.罗匹尼罗治疗不宁腿综合征。
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Ropinirole in patients with restless legs syndrome and baseline IRLS total scores ≥ 24: efficacy and tolerability in a 26-week, double-blind, parallel-group, placebo-controlled study followed by a 40-week open-label extension.罗匹尼罗治疗基线 IRLS 总分≥24 的不安腿综合征患者：26 周双盲、平行分组、安慰剂对照研究及随后 40 周开放性扩展研究的疗效和耐受性。
Clin Ther. 2013 Sep;35(9):1321-36. doi: 10.1016/j.clinthera.2013.06.016. Epub 2013 Aug 9.
6
Ropinirole decreases periodic leg movements and improves sleep parameters in patients with restless legs syndrome.罗匹尼罗可减少不宁腿综合征患者的周期性腿部运动，并改善睡眠参数。
Sleep. 2004 Aug 1;27(5):907-14. doi: 10.1093/sleep/27.5.907.
7
Ropinirole in the treatment of restless legs syndrome.罗匹尼罗用于治疗不宁腿综合征。
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Randomized, double-blind, placebo-controlled, short-term trial of ropinirole in restless legs syndrome.罗匹尼罗治疗不宁腿综合征的随机、双盲、安慰剂对照短期试验
Sleep Med. 2005 Mar;6(2):141-7. doi: 10.1016/j.sleep.2004.12.002.
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Ropinirole in the treatment of restless legs syndrome: results from the TREAT RLS 1 study, a 12 week, randomised, placebo controlled study in 10 European countries.罗匹尼罗治疗不宁腿综合征：TREAT RLS 1研究结果，一项在10个欧洲国家进行的为期12周的随机、安慰剂对照研究。
J Neurol Neurosurg Psychiatry. 2004 Jan;75(1):92-7.
10
Ropinirole treatment for restless legs syndrome.罗匹尼罗治疗不宁腿综合征。
Expert Opin Pharmacother. 2008 Mar;9(4):611-23. doi: 10.1517/14656566.9.4.611.

本文引用的文献

1
A double-blind, randomized, controlled trial to compare the efficacy and tolerability of fixed doses of ropinirole, bupropion, and iron in treatment of restless legs syndrome (Willis-Ekbom disease).一项双盲、随机、对照试验，比较固定剂量的罗匹尼罗、安非他酮和铁剂治疗不安腿综合征（ Willis-Ekbom病）的疗效和耐受性。
Ann Indian Acad Neurol. 2016 Oct-Dec;19(4):472-477. doi: 10.4103/0972-2327.194424.
2
Common pitfalls in statistical analysis: Intention-to-treat versus per-protocol analysis.统计分析中的常见陷阱：意向性分析与符合方案分析。
Perspect Clin Res. 2016 Jul-Sep;7(3):144-6. doi: 10.4103/2229-3485.184823.
3
Examination of participant flow in the CONSORT diagram can improve the understanding of the generalizability of study results.查看CONSORT流程图中的受试者流程有助于更好地理解研究结果的可推广性。
J Clin Psychiatry. 2015 Nov;76(11):e1469-71. doi: 10.4088/JCP.15f10436.
4
Poor reporting quality of key Randomization and Allocation Concealment details is still prevalent among published RCTs in 2011: a review.2011 年发表的随机对照试验中，关键的随机分组和分配隐藏细节报告质量差的情况仍然普遍存在：一项综述。
J Eval Clin Pract. 2013 Aug;19(4):703-7. doi: 10.1111/jep.12031. Epub 2013 May 7.
5
The treatment of restless legs syndrome and periodic limb movement disorder in adults--an update for 2012: practice parameters with an evidence-based systematic review and meta-analyses: an American Academy of Sleep Medicine Clinical Practice Guideline.成人不安腿综合征和周期性肢体运动障碍的治疗——2012 年更新：基于证据的系统评价和荟萃分析的实践参数：美国睡眠医学学会临床实践指南。
Sleep. 2012 Aug 1;35(8):1039-62. doi: 10.5665/sleep.1988.
6
Iron for restless legs syndrome.用于治疗不宁腿综合征的铁剂
Cochrane Database Syst Rev. 2012 May 16;5(5):CD007834. doi: 10.1002/14651858.CD007834.pub2.
7
Head to head comparisons as an alternative to placebo-controlled trials.头对头比较作为安慰剂对照试验的替代方法。
Eur Neuropsychopharmacol. 2012 Nov;22(11):800-3. doi: 10.1016/j.euroneuro.2011.11.011. Epub 2011 Dec 26.
8
Bupropion and restless legs syndrome: a randomized controlled trial.安非他酮与不宁腿综合征：一项随机对照试验。
J Am Board Fam Med. 2011 Jul-Aug;24(4):422-8. doi: 10.3122/jabfm.2011.04.100173.
9
Dopamine agonists for restless legs syndrome.用于治疗不宁腿综合征的多巴胺激动剂。
Cochrane Database Syst Rev. 2011 Mar 16;2011(3):CD006009. doi: 10.1002/14651858.CD006009.pub2.

Bupropion and Iron for Restless Leg Syndrome: Do They Have Efficacy Similar to Ropinirole?

作者信息

Praharaj Samir Kumar

机构信息

Department of Psychiatry, Kasturba Medical College, Manipal, Karnataka, India.

出版信息

Ann Indian Acad Neurol. 2017 Apr-Jun;20(2):166-167. doi: 10.4103/0972-2327.205775.

DOI:10.4103/0972-2327.205775
PMID:28615911
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5470148/
Abstract
摘要