Smith D F
Pharmacopsychiatry. 1985 May;18(3):225-30. doi: 10.1055/s-2007-1017370.
Stereoisomers have been used as tools to investigate the role of spatial (3-dimensional) features in neurochemical and behavioral effects of psychotropic drugs. Studies using enantiomers (optical isomers), geometrical isomers and semi-rigid molecules have shown that spatial features play a role in effects of antidepressant, antipsychotic, antiparkinsonian, and antianxiety drugs, as well as stimulants and psychotomimetics. An understanding of the role of spatial features in effects of psychotropic drugs might aid in reducing their side effects and in enhancing their therapeutic efficacy.
立体异构体已被用作工具，以研究空间（三维）特征在精神药物的神经化学和行为效应中的作用。使用对映体（光学异构体）、几何异构体和半刚性分子的研究表明，空间特征在抗抑郁药、抗精神病药、抗帕金森病药和抗焦虑药以及兴奋剂和拟精神病药物的效应中发挥作用。了解空间特征在精神药物效应中的作用可能有助于减少其副作用并提高其治疗效果。
