González-Díaz Sandra Nora, Arias-Cruz Alfredo, Elizondo-Villarreal Bárbara, Monge-Ortega Olga Patricia
Department of Allergy and Clinical Immunology Service, University Hospital "Dr. José Eleuterio González" Autonomous University of Nuevo Leon (UANL), Monterrey, Nuevo León 64460 Mexico.
World Allergy Organ J. 2017 Jun 6;10(1):19. doi: 10.1186/s40413-017-0151-6. eCollection 2017.
Psychoneuroimmunoendocrinology, which was first described in 1936, is the study of the interactions between the psyche, neural and endocrine functions and immune responses. The aim of psychoneuroimmunoendocrinology is to apply medical knowledge to the treatment of different allergic, immune, autoimmune, rheumatic, neoplastic, endocrine, cardiovascular and dental pathologies, among other disorders. Epigenetic factors and major stresses from different types of stimuli acting through distinct pathways and neurotransmitters are highly involved in altering the psychoneuroimmunoendocrine axis, resulting in the emergence of disease. The main purpose of this report is to expand the understanding of psychoneuroimmunoendocrinology and to demonstrate the importance of the above-mentioned interactions in the etiology of multiple pathologies. In this review, a search of the medical literature using PubMed (free access search engine for the Medline database of the National Library of Medicine of the United States) over the years 1936 to 2016 was conducted, and descriptive and experimental studies and reviews of the scientific literature were included.
心理神经免疫内分泌学于1936年首次被描述，是一门研究心理、神经和内分泌功能与免疫反应之间相互作用的学科。心理神经免疫内分泌学的目的是将医学知识应用于治疗各种过敏、免疫、自身免疫、风湿、肿瘤、内分泌、心血管和牙科疾病以及其他病症。表观遗传因素以及来自不同类型刺激的主要应激通过不同途径和神经递质发挥作用，高度参与改变心理神经免疫内分泌轴，从而导致疾病的出现。本报告的主要目的是扩展对心理神经免疫内分泌学的理解，并证明上述相互作用在多种病症病因学中的重要性。在本综述中，我们利用美国国立医学图书馆Medline数据库的免费搜索引擎PubMed，对1936年至2016年期间的医学文献进行了检索，并纳入了科学文献的描述性和实验性研究及综述。
