Fernández Suárez Félix Ezequiel, Fernández Del Valle David, González Alvarez Adrián, Pérez-Lozano Blanca
Department of Anesthesiology, Central University Hospital of Asturias, Oviedo, Asturias, Spain.
J Thorac Dis. 2017 May;9(Suppl 6):S508-S520. doi: 10.21037/jtd.2017.04.67.
The total circulatory arrest (CA) is necessary to achieve optimal surgical conditions in certain aortic pathologies, especially in those affecting the ascending aorta and aortic arch. During this procedure it is necessary to protect all the organs of ischemia, especially those of the central nervous system and for this purpose several strategies have been developed. The first and most important protective method is systemic hypothermia. The degree of hypothermia and the route of application have been evolving and currently tend to use moderate hypothermia (MH) (20.1-28 °C) associated with unilateral or bilateral selective cerebral perfusion methods. In this way the neurological results are better, the interval of security is greater and the times of extracorporeal circulation are smaller. Even so, it is necessary to take into account that there is the possibility of ischemia in the lower part of the body, especially of the abdominal viscera and the spinal cord, therefore the time of circulatory stop should be limited and not to exceed 80 minutes. Evidence of possible neurological drug protection is very weak and only mannitol, magnesium, and statins can produce some benefit. Inhalational anesthetics and some intravenous seem to have advantages, but more studies would be needed to test their long-term benefit. Other important parameters to be monitored during these procedures are blood glucose, anemia and coagulation disorders and acid-base balance. The recommended monitoring is common in complex cardiovascular procedures and it is of special importance the neurological monitoring that can be performed with several techniques, although currently the most used are Bispectral Index (BIS) and Near-Infrared Spectroscopy (NIRS). It is also essential to monitor the temperature routinely at the nasopharyngeal and bladder level and it is important to control coagulation with rotational thromboelastometry (ROTEM).
在某些主动脉病变,尤其是累及升主动脉和主动脉弓的病变中,完全循环骤停(CA)对于实现最佳手术条件是必要的。在此过程中,有必要保护所有易缺血的器官,尤其是中枢神经系统的器官,为此已开发了多种策略。首要且最重要的保护方法是全身低温。低温的程度和应用途径一直在不断发展,目前倾向于使用与单侧或双侧选择性脑灌注方法相结合的中度低温(MH)(20.1 - 28℃)。通过这种方式,神经学结果更好,安全间隔更大,体外循环时间更短。即便如此,仍需考虑身体下部,尤其是腹部脏器和脊髓存在缺血的可能性,因此循环停止时间应受限,且不超过80分钟。可能的神经药物保护证据非常薄弱,只有甘露醇、镁和他汀类药物能产生一些益处。吸入性麻醉剂和一些静脉用药似乎有优势,但需要更多研究来检验它们的长期益处。在这些手术过程中要监测的其他重要参数包括血糖、贫血、凝血障碍和酸碱平衡。推荐的监测在复杂心血管手术中很常见,神经学监测尤为重要,可通过多种技术进行,尽管目前最常用的是脑电双频指数(BIS)和近红外光谱(NIRS)。常规监测鼻咽部和膀胱水平的温度也至关重要,通过旋转血栓弹力图(ROTEM)控制凝血也很重要。