相互作用组分析揭示蛋白磷酸酶在受体酪氨酸激酶信号传导中的多种功能。
Multiple functions of protein phosphatases in receptor tyrosine kinase signaling revealed by interactome analysis.
作者信息
Yao Zhong, Stagljar Igor
机构信息
Donnelly Centre, University of Toronto, Toronto, ON, Canada.
Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
出版信息
Mol Cell Oncol. 2017 Feb 26;4(3):e1297101. doi: 10.1080/23723556.2017.1297101. eCollection 2017.
Abstract
To obtain a global picture of how protein phosphatases are involved in receptor tyrosine kinase (RTK) signaling, we mapped the RTK-phosphatase interactome. Analyses of selected interactions revealed detailed mechanisms of their actions. This study provides new knowledge to better understand cancer development and to identify novel therapeutic targets.
摘要
为全面了解蛋白磷酸酶如何参与受体酪氨酸激酶（RTK）信号传导，我们绘制了RTK-磷酸酶相互作用组图谱。对选定相互作用的分析揭示了它们作用的详细机制。本研究为更好地理解癌症发展及识别新的治疗靶点提供了新知识。
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