Carter Hannah, Ideker Trey
Department of Medicine, Division of Medical Genetics, University of California San Diego, La Jolla, CA, USA.
Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.
Mol Cell Oncol. 2017 Mar 10;4(3):e1302905. doi: 10.1080/23723556.2017.1302905. eCollection 2017.
Germline variation contributes to individual risk for developing specific types of cancer. Analyzing thousands of tumors, we found evidence that the germline also influences vulnerable tissue sites and the mutations that arise in tumor genomes. These associations provide new clues to unravel the biologic mechanisms underlying cancer predisposition.
种系变异会增加个体患特定类型癌症的风险。通过分析数千个肿瘤样本，我们发现有证据表明种系也会影响易患肿瘤的组织部位以及肿瘤基因组中出现的突变。这些关联为揭示癌症易感性背后的生物学机制提供了新线索。
