Mobley W C, Rutkowski J L, Tennekoon G I, Buchanan K, Johnston M V
Science. 1985 Jul 19;229(4710):284-7. doi: 10.1126/science.2861660.
Some neurodegenerative disorders may be caused by abnormal synthesis or utilization of trophic molecules required to support neuronal survival. A test of this hypothesis requires that trophic agents specific for the affected neurons be identified. Cholinergic neurons in the corpus striatum of neonatal rats were found to respond to intracerebroventricular administration of nerve growth factor with prominent, dose-dependent, selective increases in choline acetyltransferase activity. Cholinergic neurons in the basal forebrain also respond to nerve growth factor in this way. These actions of nerve growth factor may indicate its involvement in the normal function of forebrain cholinergic neurons as well as in neurodegenerative disorders involving such cells.
一些神经退行性疾病可能是由支持神经元存活所需的营养分子的异常合成或利用引起的。对这一假设的检验需要确定对受影响神经元具有特异性的营养因子。发现新生大鼠纹状体中的胆碱能神经元对脑室内给予神经生长因子有反应，胆碱乙酰转移酶活性显著、剂量依赖性地选择性增加。基底前脑的胆碱能神经元也以这种方式对神经生长因子作出反应。神经生长因子的这些作用可能表明它参与了前脑胆碱能神经元的正常功能以及涉及此类细胞的神经退行性疾病。
