Moglia Cristina, Calvo Andrea, Canosa Antonio, Bertuzzo Davide, Cugnasco Paolo, Solero Luca, Grassano Maurizio, Bersano Enrica, Cammarosano Stefania, Manera Umberto, Pisano Fabrizio, Mazzini Letizia, Dalla Vecchia Laura A, Mora Gabriele, Chiò Adriano
a ALS Center, 'Rita Levi Montalcini' Department of Neuroscience , University of Turin , Turin , Italy.
b Azienda Ospedaliero Universitaria Città della Salute e della Scienza , Turin , Italy.
Amyotroph Lateral Scler Frontotemporal Degener. 2017 Nov;18(7-8):590-597. doi: 10.1080/21678421.2017.1336560. Epub 2017 Jun 15.
To assess the prognostic influence of pre-morbid type 2 diabetes mellitus, arterial hypertension and cardiovascular (CV) risk profile on ALS phenotype and outcome in a population-based cohort of Italian patients.
A total of 650 ALS patients from the Piemonte/Valle d'Aosta Register for ALS, incident in the 2007-2011 period, were recruited. Information about premorbid presence of type 2 diabetes mellitus, arterial hypertension was collected at the time of diagnosis. Patients' CV risk profile was calculated according to the Joint British Societies' guidelines on prevention of cardiovascular disease in clinical practice (JBS2).
At the univariate analysis, the presence of pre-morbid arterial hypertension was associated with a higher age at onset of ALS and a shorter survival, and patients with a high CV risk profile had a worse prognosis than those with a low CV risk profile. The Cox multivariable analysis did not confirm such findings. Type 2 diabetes mellitus did not modify either the phenotype or the prognosis of ALS patients.
This study performed on a large population-based cohort of ALS patients has demonstrated that arterial hypertension, type 2 diabetes and CV risk factors, calculated using the Framingham equation, do not influence ALS phenotype and prognosis.
在一个以意大利患者为基础的队列中，评估病前2型糖尿病、动脉高血压和心血管（CV）风险状况对肌萎缩侧索硬化症（ALS）表型及预后的影响。
招募了2007年至2011年期间来自皮埃蒙特/瓦莱达奥斯塔ALS登记处的650例ALS患者。在诊断时收集有关病前2型糖尿病、动脉高血压存在情况的信息。根据英国联合学会关于临床实践中预防心血管疾病的指南（JBS2）计算患者的CV风险状况。
在单因素分析中，病前动脉高血压的存在与ALS发病时较高的年龄和较短的生存期相关，且CV风险状况高的患者比CV风险状况低的患者预后更差。Cox多变量分析未证实这些发现。2型糖尿病并未改变ALS患者的表型或预后。
在一个基于大量ALS患者的队列中进行的这项研究表明，使用弗雷明汉方程计算的动脉高血压、2型糖尿病和CV危险因素不会影响ALS表型和预后。
