多沙唑嗪可增加低密度脂蛋白受体活性。
Doxazosin increases low density lipoprotein receptor activity.
作者信息
Leren T P
出版信息
Acta Pharmacol Toxicol (Copenh). 1985 Mar;56(3):269-72. doi: 10.1111/j.1600-0773.1985.tb01288.x.
Abstract
The effect of the alpha 1 adrenoreceptor antagonist doxazosin on low density lipoprotein (LDL) receptor activity, has been studied in cultured skin fibroblasts. Doxazosin at a concentration of 10(-5) M significantly increased the LDL receptor activity. The possible clinical implications of this observation are discussed.
摘要
已经在培养的皮肤成纤维细胞中研究了α1肾上腺素能受体拮抗剂多沙唑嗪对低密度脂蛋白（LDL）受体活性的影响。浓度为10^(-5) M的多沙唑嗪显著增加了LDL受体活性。讨论了这一观察结果可能的临床意义。
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