Hedlund H, Fasth S, Hultén L, Nordgren S
Acta Physiol Scand. 1985 May;124(1):43-51. doi: 10.1111/j.1748-1716.1985.tb07630.x.
The effect of sympathetic nervous activity on rectal motility induced by pelvic nerve stimulation (PNS) was studied in anaesthetized cats. Division of the sympathetic lumbar colonic and hypogastric nerves or alpha-adrenoreceptor blockade, both of which reduced rectal tone, also reversed a predominantly relaxatory pelvic nerve response into a pure contraction. Contractions to pelvic nerve stimulation were reduced by simultaneous lumbar colonic nerve stimulation. This lumbar colonic nerve-induced inhibition was augmented by alpha-adrenoceptor blockade and abolished by beta-blockade. Close intra-arterial injection of a beta-adrenergic agonist reduced contractions to PNS, while an alpha-adrenergic agonist had no effect. Stimulation of the hypogastric nerves enhanced rectal contractions to simultaneous PNS. The apparent similarity with the arrangement of extrinsic nervous control of the internal anal sphincter suggests that the rectum is functionally involved in continence mechanisms.
在麻醉猫身上研究了交感神经活动对盆腔神经刺激（PNS）诱导的直肠运动的影响。切断交感神经的腰结肠神经和腹下神经，或进行α-肾上腺素能受体阻断，这两种方法均降低了直肠张力，同时也将主要为舒张性的盆腔神经反应转变为单纯的收缩。同时刺激腰结肠神经会减少对盆腔神经刺激的收缩反应。这种腰结肠神经诱导的抑制作用在α-肾上腺素能受体阻断时增强，而在β-受体阻断时消除。经动脉内近距离注射β-肾上腺素能激动剂可减少对PNS的收缩反应，而α-肾上腺素能激动剂则无作用。刺激腹下神经可增强同时进行PNS时的直肠收缩。其与肛门内括约肌外在神经控制模式的明显相似性表明，直肠在控便机制中发挥着功能性作用。
