Fedorova Elena M, Shlykova Svetlana A, Shunkina Ksenia V, Zaitceva Olga G, Lapina Elena N, Yanchuk Taras V, Kalugina Alla S
a AVA-Peter Clinic , Saint-Petersburg , Russia.
Gynecol Endocrinol. 2017 Sep;33(9):737-740. doi: 10.1080/09513590.2017.1318274. Epub 2017 Jun 15.
It is well documented that aneuploidy rate in preimplantation embryos increases with the mother's age, and at the same time the number of oocytes diminishes. Consequently, for patients of advanced maternal age two options are available to overcome these limitations: use of oocytes from young donors, or use of own oocytes coupled with preimplantation genetic screening (PGS) for 24 chromosomes. However, it is not clear which strategy might be more effective. The aim of this retrospective study was to evaluate outcomes of IVF cycles coupled with transfer of vitrified embryos from donor or autologous oocytes, both with or without PGS. Our results demonstrate that while after PGS clinical pregnancy, twin pregnancy and spontaneous abortion rates are similar for embryos from donor and autologous oocytes, these rates are dramatically worse in all cycles without PGS. Therefore, PGS can be recommended as a screening method to all patients of advanced maternal age even when donor oocytes are used.
有充分文献记载，植入前胚胎的非整倍体率会随着母亲年龄的增加而上升，与此同时，卵母细胞数量会减少。因此，对于高龄产妇患者，有两种选择可以克服这些限制：使用年轻供体的卵母细胞，或者使用自身卵母细胞并结合对24条染色体进行植入前基因筛查（PGS）。然而，尚不清楚哪种策略可能更有效。这项回顾性研究的目的是评估体外受精周期的结果，以及移植来自供体或自体卵母细胞的玻璃化胚胎的结果，无论是否进行PGS。我们的结果表明，虽然在进行PGS后，来自供体和自体卵母细胞的胚胎的临床妊娠率、双胎妊娠率和自然流产率相似，但在所有未进行PGS的周期中，这些比率都明显更差。因此，即使使用供体卵母细胞，也可以向所有高龄产妇患者推荐PGS作为一种筛查方法。
