肾移植中的膀胱输尿管反流
Vesicoureteral Reflux in Kidney Transplantation.
作者信息
Molenaar Nina M, Minnee Robert C, Bemelman Frederike J, Idu Mirza M
机构信息
1 Department of Surgery, Academic Medical Center Amsterdam, Amsterdam, the Netherlands.
2 Renal Transplant Unit, Department of Nephrology, Academic Medical Center Amsterdam, Amsterdam, the Netherlands.
出版信息
Prog Transplant. 2017 Jun;27(2):196-199. doi: 10.1177/1526924817699965. Epub 2017 Mar 22.
BACKGROUND
Vesicoureteral reflux (VUR) is frequently found after transplantation, but its impact on graft function, urine tract infection, and graft loss remains uncertain. Therefore our objective was to evaluate the effects of VUR on the outcome of renal transplantation.
MATERIAL AND METHODS
We included 1008 adult renal transplant recipients of whom a 1-week posttransplant voiding cystourethrogram was available. Study end points included occurrence of bacteriuria, renal function, and graft survival.
RESULTS
In total, 106 (10.5%) of 1008 graft recipients had a diagnosis of VUR on voiding cystography. The incidence of bacteriuria was comparable in the reflux and nonreflux group (17% vs 17.4%, P = .91). There was no significant difference in renal function at 3 months and 1 year in patients with and without VUR. One- and 5-year graft survival in patients with VUR was 85.8% and 82.1% compared to 87.3% and 83.0% in patients without VUR ( P = .68 and P = .80).
CONCLUSION
Posttransplant VUR has no correlations with early bacteriuria, renal function, and graft survival.
背景
膀胱输尿管反流（VUR）在肾移植后很常见，但其对移植肾功能、尿路感染和移植肾丢失的影响仍不确定。因此，我们的目的是评估VUR对肾移植结局的影响。
材料与方法
我们纳入了1008例成年肾移植受者，他们在移植后1周进行了排尿性膀胱尿道造影。研究终点包括菌尿的发生、肾功能和移植肾存活情况。
结果
1008例移植受者中，共有106例（10.5%）在排尿性膀胱造影时被诊断为VUR。反流组和无反流组的菌尿发生率相当（17%对17.4%，P = 0.91）。有VUR和无VUR的患者在3个月和1年时的肾功能无显著差异。VUR患者的1年和5年移植肾存活率分别为85.8%和82.1%，无VUR患者分别为87.3%和83.0%（P = 0.68和P = 0.80）。
结论
移植后VUR与早期菌尿、肾功能和移植肾存活无关。
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