成骨细胞在风湿性疾病中的作用。
Osteoblast Role in Rheumatic Diseases.
作者信息
Corrado Addolorata, Maruotti Nicola, Cantatore Francesco Paolo
机构信息
Rheumatology Clinic, Department of Medical and Surgical Sciences, University of Foggia Medical School, 71122 Foggia, Italy.
出版信息
Int J Mol Sci. 2017 Jun 15;18(6):1272. doi: 10.3390/ijms18061272.
Abstract
Alterations in osteoblast growth, differentiation and activity play a role in the pathogenesis of several rheumatic diseases, such as rheumatoid arthritis, spondyloarthritides, osteoarthritis, and osteoporosis. In fact, in these rheumatic diseases, abnormal activity of Wnt signaling, receptor activator of nuclear factor-κB (RANK)-RANK ligand (RANKL)-osteoprotegerin (OPG) signaling, bone morphogenetic proteins (BMPs) pathway and other mechanisms have been described in osteoblasts. This review article is focused on current knowledge on the role of osteoblast dysregulation occurring in rheumatic diseases.
摘要
成骨细胞生长、分化和活性的改变在几种风湿性疾病的发病机制中起作用，如类风湿关节炎、脊柱关节炎、骨关节炎和骨质疏松症。事实上，在这些风湿性疾病中，成骨细胞中已发现Wnt信号、核因子κB受体激活剂（RANK）-RANK配体（RANKL）-骨保护素（OPG）信号、骨形态发生蛋白（BMP）通路及其他机制存在异常活性。本文综述聚焦于风湿性疾病中发生的成骨细胞失调作用的现有知识。
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