Department of Medical and Surgical Science and Translation Medicine, Sant'Andrea Hospital, School of Medicine and Psychology, Sapienza University of Rome, Rome, Italy.
Eur Rev Med Pharmacol Sci. 2017 May;21(10):2504-2511.
The aim of the study was to evaluate the relationship between bacterial vaginosis (BV) and relapse of cervical intraepithelial neoplasia grade 2 or more (CIN2+) after Loop electrosurgical excision procedure (LEEP).
One hundred four patients who underwent LEEP for CIN2+ were followed up every six months for three years. Fifty-three were negative for BV and fifty-one were positive. Each clinical control included Pap test, colposcopy, Amsel criteria test, HPV-DNA, and HPV-mRNA test.
Patients' age, presence of BV, positivity to HPV-DNA and HPV-mRNA tests were analyzed. The average age of patients was 42.5 ± 8.92 years (median: 42.5; range from 27 to 58 years). The minimum follow-up was 6 months and maximum 36 months (average: 22.8 ± 4.53; median: 24). The 10% of the patients with HPV-mRNA test negative had relapsed, compared to 45% of patients with HPV-mRNA test positive. Among the 53 patients without BV the 20% had relapsed compared with 23% of 51 patients with diagnosis of BV.
There is no evidence for higher percentage of relapse in patients with BV, submitted to excisional procedure for CIN2+ associated to HPV-m-RNA test positivity. There is only a correlation among BV and relapse of CIN2+ lesions after LEEP.
本研究旨在评估细菌性阴道病（BV）与宫颈上皮内瘤变 2 级及以上（CIN2+）经环形电切术（LEEP）后复发的关系。
104 例 CIN2+患者行 LEEP 治疗，随访 3 年，每 6 个月 1 次。其中 53 例 BV 阴性，51 例 BV 阳性。每次临床随访均行巴氏涂片、阴道镜、Amsel 标准检查、HPV-DNA 和 HPV-mRNA 检测。
分析患者年龄、BV 存在情况、HPV-DNA 和 HPV-mRNA 检测阳性率。患者平均年龄 42.5±8.92 岁（中位数：42.5；范围：27-58 岁）。最短随访 6 个月，最长 36 个月（平均：22.8±4.53；中位数：24）。HPV-mRNA 检测阴性的患者中 10%复发，而 HPV-mRNA 检测阳性的患者中 45%复发。53 例无 BV 的患者中，20%复发，51 例诊断为 BV 的患者中，23%复发。
HPV-mRNA 检测阳性的 CIN2+患者行 LEEP 术后，BV 与复发无显著相关性。BV 与 LEEP 术后 CIN2+病变复发之间仅存在相关性。
