Ercan Z S, Türker R K
Arch Int Pharmacodyn Ther. 1985 Mar;274(1):24-30.
The effects of nicotine on histamine-induced contractions in the aortic strip from rabbit and in the intestinal and airway smooth muscles from guinea-pig were examined. Nicotine inhibited the contractile effects of histamine in a concentration-dependent manner in all investigated smooth muscle preparations having identical pA2 values. Data obtained in this study indicate that nicotine has a histamine H1-receptor antagonistic property with a lower activity than mepyramine for H1-receptors as verified by the calculated pA2 values.
研究了尼古丁对兔主动脉条以及豚鼠肠道和气道平滑肌中组胺诱导的收缩的影响。在所有具有相同pA2值的被研究平滑肌制剂中，尼古丁以浓度依赖性方式抑制组胺的收缩作用。本研究获得的数据表明，尼古丁具有组胺H1受体拮抗特性，经计算的pA2值验证，其对H1受体的活性低于美吡拉敏。
