Papagiannopoulou Dionysia
Department of Pharmaceutical Chemistry, School of Pharmacy, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.
J Labelled Comp Radiopharm. 2017 Sep;60(11):502-520. doi: 10.1002/jlcr.3531. Epub 2017 Aug 28.
Technetium-99m ( Tc) is a widely used radionuclide, and the development of Tc imaging agents continues to be in demand. This overview discusses basic principles of Tc radiopharmaceutical preparation and design and focuses on the Tc radiochemistry relevant to its pharmaceutical applications. The Tc complexes are described based on the most typical examples in each category, keeping up with the state-of-the-art in the field. In addition, the main current strategies to develop targeted Tc radiopharmaceuticals are summarized.
锝-99m（Tc）是一种广泛使用的放射性核素，对Tc显像剂的开发需求持续存在。本综述讨论了Tc放射性药物制备和设计的基本原理，并重点关注与其药物应用相关的Tc放射化学。基于每一类中最典型的例子对Tc配合物进行了描述，紧跟该领域的最新进展。此外，还总结了目前开发靶向Tc放射性药物的主要策略。
