细想一下，让你的氯离子发挥作用，因为细菌清除依赖于它。
Relish the Thought and Channel Your Chloride, for Bacterial Clearance Depends on It.
机构信息
Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
出版信息
Cell Host Microbe. 2017 Jun 14;21(6):657-659. doi: 10.1016/j.chom.2017.05.013.
Macrophage-mediated bacterial clearance relies on phagocytic uptake of the pathogen, subsequent phagolysosomal maturation, and microbial degradation. In this issue of Cell Host & Microbe, Wong et al. (2017) report that a chloride transporter couples phagocytosis and bacterial clearance in an NF-κB-mediated feedforward loop, which is required for sustained pathogen uptake.
巨噬细胞介导的细菌清除依赖于病原体的吞噬作用、随后的吞噬体成熟和微生物降解。在本期《细胞宿主与微生物》中，Wong 等人（2017）报告称，氯离子转运蛋白通过 NF-κB 介导的正反馈环偶联吞噬作用和细菌清除，这是持续摄取病原体所必需的。
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