Laboratory of Histology and Embryology, Faculty of Medicine of Sfax, University of Sfax, Tunisia.
Urology Department, Habib Bourguiba University Hospital, Sfax, Tunisia.
Turk J Med Sci. 2017 Jun 12;47(3):902-907. doi: 10.3906/sag-1605-47.
BACKGROUND/AIM: Concerns about the detrimental effects of occupational and environmental exposure on male reproductive function have been raised by reports of declining sperm quality over the last decades. The aim of this study was to investigate the association between altered semen parameters and exposure to occupational risk factors as assessed by questionnaire.
We conducted a cross-sectional questionnaire-based study among a population of 2122 men who underwent andrological investigation for couple infertility. All participants were interviewed and their semen samples were analyzed. Information about medical history and occupational exposure was used to classify participants into exposed and unexposed groups.
Exposure to pesticides was associated with a significantly higher risk of asthenozoospermia (adjusted odds ratio [OR] = 1.6; 95% CI, 1.0-2.4) and necrozoospermia (OR = 2.6; 95% CI, 1.4-4.7). Exposure to cement was found to be correlated with a higher risk of oligozoospermia (OR = 1.1; 95% CI, 0.9-1.4). There was no association between semen impairment and exposure to solvents, excess heat, or mechanical vibrations.
We found an association between self-reported occupational exposure and altered semen parameters. These results support the usefulness of questionnaires for routine assessment and management of occupational exposures in infertile men.
背景/目的：过去几十年来，有关职业和环境暴露对男性生殖功能有害影响的担忧报告不断增加，人们对精子质量下降表示关注。本研究旨在通过问卷调查评估，研究精液参数改变与职业危险因素暴露之间的关联。
我们对 2122 名因夫妇不孕而接受男科检查的人群进行了一项基于问卷调查的横断面研究。所有参与者都接受了访谈并分析了他们的精液样本。根据病史和职业暴露信息，将参与者分为暴露组和未暴露组。
接触杀虫剂与弱精子症（调整后的优势比 [OR] = 1.6；95%可信区间，1.0-2.4）和死精子症（OR = 2.6；95%可信区间，1.4-4.7）的风险显著增加相关。接触水泥与少精子症（OR = 1.1；95%可信区间，0.9-1.4）的风险增加相关。接触溶剂、过热或机械振动与精液损害之间没有关联。
我们发现职业暴露与精液参数改变之间存在关联。这些结果支持使用问卷对不育男性的职业暴露进行常规评估和管理。
