Center of Excellence for Biodiversity, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.
Liver and Gastrointestinal Research Center, Tabriz University of Medical Science, Tabriz, Iran.
Turk J Med Sci. 2017 Jun 12;47(3):778-781. doi: 10.3906/sag-1511-67.
BACKGROUND/AIM: Recurrent pregnancy loss (RPL) is defined as two or more pregnancy losses. T-regulatory cells play an important role in the feto-maternal interface. Cytotoxic-T-lymphocyte antigen-4 (CTLA-4) is a molecule that downregulates the activation and proliferation of T cells. The objective of the current study was to investigate the possible association of CTLA-4+49A/G gene polymorphism with RPL among patients from the Iranian Azeri Turkish ethnic group.
The study group/patients consisted of 101 women with the experience of two or more pregnancy losses and the control group consisted of 101 women with at least two live births, without any previous history of pregnancy loss and autoimmune diseases from the same ethnic group. The was detected by polymerase chain reaction-restriction fragment length polymorphisms assay.
The distribution of CTLA-4+49A/G genotype was AA, 38.61%; AG, 51.48%; GG, 9.9% in patients and AA, 37.62%; AG, 47.52%; GG,14.85% in controls (P-value: 0.2). Furthermore, no association in G-allele was observed in the patient and control groups (P-value: 0.5).
The results of the present study suggest that does not have any association with RPL in the Iranian Azeri Turkish ethnic group.
背景/目的：复发性流产（RPL）定义为两次或更多次妊娠丢失。调节性 T 细胞在胎母界面中发挥重要作用。细胞毒性 T 淋巴细胞抗原 4（CTLA-4）是一种下调 T 细胞激活和增殖的分子。本研究的目的是探讨 CTLA-4+49A/G 基因多态性与伊朗阿塞拜疆土耳其族患者 RPL 之间的可能关联。
研究组/患者包括 101 名有两次或更多次妊娠丢失史的妇女，对照组包括 101 名至少有两次活产且无妊娠丢失和自身免疫性疾病史的同一族裔妇女。采用聚合酶链反应-限制性片段长度多态性检测法检测 。
患者组 CTLA-4+49A/G 基因型分布为 AA（38.61%）、AG（51.48%）、GG（9.9%），对照组为 AA（37.62%）、AG（47.52%）、GG（14.85%）（P 值：0.2）。此外，患者和对照组的 G 等位基因均无关联（P 值：0.5）。
本研究结果表明，在伊朗阿塞拜疆土耳其族中， 与 RPL 无关。
