Athanerey Anjali, Patra Pradeep Kumar, Kumar Awanish
Department of Biotechnology, National Institute of Technology Raipur, Chhattisgarh, India.
Department of Biochemistry, Pt. JNM Medical College, Raipur, Chhattisgarh, India.
J Tissue Viability. 2017 Aug;26(3):216-223. doi: 10.1016/j.jtv.2017.06.001. Epub 2017 Jun 7.
Venous leg ulcers (VLU) are a prevalent and reoccurring type of complicated wound, turning as a considerable public healthcare issue, with critical social and economic concern. There are both medical and surgical therapies to treat venous leg ulcers; however, a cure does not yet exist. Mesenchymal stem cells (MSC) are capable and proved of accelerating wound healing in vivo and their study with human chronic wounds is currently awaited. MSCs are a promising source of adult progenitor cells for cellular therapy and have been demonstrated to differentiate into various mesenchymal cell lineages. They have a crucial and integral role in native wound healing by regulating immune response and inflammation. Improved understanding of the cellular and molecular mechanisms at work in delayed wound healing compels to the development of cellular therapy in VLU. This review focuses on the current treatment option of VLU and further emphasizing the role of MSCs in accelerating the healing process. With further understanding of the mechanism of action of these cells in wound improvement and, the involvement of cytokines can also be revealed that could be used for the therapeutic purpose for VLU healing. Clinical uses of MSCs have been started already, and induced MSCs are surely a promising tool or compelling therapy for VLU.
下肢静脉溃疡（VLU）是一种常见且易复发的复杂伤口，已成为一个重大的公共卫生问题，引起了社会和经济方面的严重关注。治疗下肢静脉溃疡有医学和外科两种疗法；然而，目前尚无治愈方法。间充质干细胞（MSC）已被证明能够在体内加速伤口愈合，目前人们正期待着对其在人类慢性伤口方面的研究结果。间充质干细胞是细胞治疗中很有前景的成体祖细胞来源，并且已被证明可分化为各种间充质细胞谱系。它们通过调节免疫反应和炎症在天然伤口愈合中发挥着关键且不可或缺的作用。对延迟伤口愈合中细胞和分子机制的深入了解促使人们在下肢静脉溃疡中开展细胞治疗。本综述重点关注下肢静脉溃疡的当前治疗选择，并进一步强调间充质干细胞在加速愈合过程中的作用。随着对这些细胞在伤口改善中作用机制的进一步了解，还可揭示细胞因子的参与情况，这些细胞因子可用于下肢静脉溃疡愈合的治疗目的。间充质干细胞的临床应用已经开始，诱导间充质干细胞肯定是治疗下肢静脉溃疡的一种有前景的工具或令人信服的疗法。
