胰岛素依赖型低分子量化合物的产生，这些化合物可修饰代谢中的关键酶。

Insulin-dependent production of low-molecular-weight compounds that modify key enzymes in metabolism.

作者信息

Stevens E V, Husbands D R

出版信息

Comp Biochem Physiol B. 1985;81(1):1-8. doi: 10.1016/0305-0491(85)90155-5.

DOI:10.1016/0305-0491(85)90155-5

Abstract

The mechanism by which the metabolic effects of insulin are transmitted is yet to be resolved. Second messengers mediating the action of insulin have been proposed and recently an insulin-dependent, peptide-like, heat- and acid-stable substance (Mr approx. 1000-3000) released from plasma membranes has been described which regulates the activity of key enzymes such as pyruvate dehydrogenase by altering its state of phosphorylation. It has been suggested that this material is the elusive second messenger of insulin and its discovery, generation, properties, isolation and mode of action are reviewed.

摘要

胰岛素代谢作用的传导机制尚待阐明。人们已经提出了介导胰岛素作用的第二信使，最近有报道称，从质膜释放出一种胰岛素依赖性、类似肽、耐热且耐酸的物质（分子量约为1000 - 3000），该物质通过改变丙酮酸脱氢酶等关键酶的磷酸化状态来调节其活性。有人认为这种物质就是难以捉摸的胰岛素第二信使，本文对其发现、生成、特性、分离及作用方式进行了综述。

相似文献

1

Insulin-dependent production of low-molecular-weight compounds that modify key enzymes in metabolism.胰岛素依赖型低分子量化合物的产生，这些化合物可修饰代谢中的关键酶。

Comp Biochem Physiol B. 1985;81(1):1-8. doi: 10.1016/0305-0491(85)90155-5.

2

Hormonal control of adipose tissue lipolysis.脂肪组织脂解作用的激素调控

Proc Nutr Soc. 1975 Dec;34(3):233-9. doi: 10.1079/pns19750044.

3

Intracellular mediators of insulin action.

Diabetes Metab Rev. 1985;1(3):229-59. doi: 10.1002/dmr.5610010302.

4

Chemical mediator or mediators of insulin action: response to insulin and mode of action.

Fed Proc. 1982 Sep;41(11):2736-41.

5

The role of phosphorylation in the regulation of fatty acid synthesis by insulin and other hormones.磷酸化在胰岛素及其他激素对脂肪酸合成的调节中的作用。

Philos Trans R Soc Lond B Biol Sci. 1983 Jul 5;302(1108):33-45. doi: 10.1098/rstb.1983.0036.

6

Insulin generates an enzyme modulator from hepatic plasma membranes: regulation of adenosine 3',5'-monophosphate phosphodiesterase, pyruvate dehydrogenase, and adenylate cyclase.胰岛素可从肝细胞膜生成一种酶调节剂：对3',5'-环磷酸腺苷磷酸二酯酶、丙酮酸脱氢酶及腺苷酸环化酶的调节作用。

Endocrinology. 1987 Mar;120(3):967-72. doi: 10.1210/endo-120-3-967.

7

Alterations in enzymes related to adenosine 3',5'-monophosphate during compensatory growth of rat lung.大鼠肺代偿性生长过程中与3',5'-环磷酸腺苷相关的酶的变化

Eur J Biochem. 1980 Apr;105(2):403-7. doi: 10.1111/j.1432-1033.1980.tb04514.x.

8

Partial purification from hepatoma cells of an intracellular substance which mediates the effects of insulin on pyruvate dehydrogenase and low Km cyclic AMP phosphodiesterase.从肝癌细胞中部分纯化一种细胞内物质，该物质介导胰岛素对丙酮酸脱氢酶和低 Km 环磷酸腺苷磷酸二酯酶的作用。

Arch Biochem Biophys. 1982 Apr 15;215(1):339-44. doi: 10.1016/0003-9861(82)90312-5.

9

Putative mediators of insulin action regulate hepatic acetyl CoA carboxylase activity.胰岛素作用的假定介质调节肝脏乙酰辅酶A羧化酶活性。

Biochem Biophys Res Commun. 1983 Feb 10;110(3):789-95. doi: 10.1016/0006-291x(83)91031-8.

10

Insulin release in aging: studies on adenylate cyclase, phosphodiesterase, and protein kinase in isolated islets of Langerhans of the rat.衰老过程中的胰岛素释放：对大鼠胰岛朗格汉斯细胞中腺苷酸环化酶、磷酸二酯酶和蛋白激酶的研究。

Endocrinology. 1981 Feb;108(2):620-4. doi: 10.1210/endo-108-2-620.

引用本文的文献

1

Insulin-dependent changes in lysosomal cathepsin D activity in rat liver, kidney, brain and heart.胰岛素依赖性大鼠肝脏、肾脏、大脑和心脏中溶酶体组织蛋白酶D活性的变化。

Diabetologia. 1988 Feb;31(2):119-22. doi: 10.1007/BF00395559.

2

Effect of chronic exercise on glucose uptake and activities of glycolytic enzymes measured regionally in rat heart.

Basic Res Cardiol. 1989 Mar-Apr;84(2):174-90. doi: 10.1007/BF01907927.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

文档翻译

学术文献翻译模型，支持多种主流文档格式。