Nerurkar M A, Satav J G, Katyare S S
Biochemistry Division, Bhabha Atomic Research Centre, Bombay, India.
Diabetologia. 1988 Feb;31(2):119-22. doi: 10.1007/BF00395559.
Streptozotocin-induced diabetes resulted in a decrease in the cathepsin D activity (free and total) in rat liver, kidney, brain and heart with a concomitant increase in tissue protein content and amino acids pool size. Treatment with insulin brought about the restoration of the cathepsin D activity to normal or greater than normal levels; tissue protein content and amino acids pool size also returned to normal values.
链脲佐菌素诱导的糖尿病导致大鼠肝脏、肾脏、大脑和心脏中组织蛋白酶D活性（游离型和总活性）降低，同时组织蛋白含量和氨基酸库大小增加。胰岛素治疗使组织蛋白酶D活性恢复到正常或高于正常水平；组织蛋白含量和氨基酸库大小也恢复到正常值。
