Cancer Discov. 2017 Aug;7(8):OF6. doi: 10.1158/2159-8290.CD-NB2017-092. Epub 2017 Jun 15.
A new study of all 32 cancer types in The Cancer Genome Atlas identifies genomic alterations that increase the activity of the PI3K/AKT/mTOR pathway. The study, which combines mutation data with measures of protein levels and phosphorylation status, suggests that mutations in , and promote activation of the pathway and may point to new drug targets.
一项对癌症基因组图谱中所有 32 种癌症类型的新研究确定了增加 PI3K/AKT/mTOR 通路活性的基因组改变。该研究结合了突变数据与蛋白质水平和磷酸化状态的测量结果，表明 和 的突变促进了通路的激活，并可能指向新的药物靶点。
