May Benjamin, Young Luke, Moore Anthony L
Biochemistry and Biomedicine, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, U.K.
Biochem Soc Trans. 2017 Jun 15;45(3):731-740. doi: 10.1042/BST20160178.
The alternative oxidases (AOXs) are ubiquinol-oxidoreductases that are members of the diiron carboxylate superfamily. They are not only ubiquitously distributed within the plant kingdom but also found in increasing numbers within the fungal, protist, animal and prokaryotic kingdoms. Although functions of AOXs are highly diverse in general, they tend to play key roles in thermogenesis, stress tolerance (through the management of radical oxygen species) and the maintenance of mitochondrial and cellular energy homeostasis. The best structurally characterised AOX is from In this review, we compare the structure of AOXs, created using homology modelling, from many important species in an attempt to explain differences in activity and sensitivity to AOX inhibitors. We discuss the implications of these findings not only for future structure-based drug design but also for the design of novel AOXs for gene therapy.
交替氧化酶（AOXs）是泛醌氧化还原酶，属于二价铁羧酸盐超家族成员。它们不仅在植物界广泛分布，而且在真菌、原生生物、动物和原核生物界中的数量也在不断增加。尽管AOXs的功能总体上高度多样，但它们往往在产热、胁迫耐受性（通过管理活性氧）以及维持线粒体和细胞能量稳态中发挥关键作用。结构表征最完善的AOX来自于……在本综述中，我们比较了通过同源建模创建的来自许多重要物种的AOXs结构，试图解释其活性差异以及对AOX抑制剂的敏感性。我们不仅讨论了这些发现对未来基于结构的药物设计的意义，还讨论了其对用于基因治疗的新型AOXs设计的意义。
