Honda K, Negoro H, Fukuoka T, Higuchi T, Uchide K
Endocrinol Jpn. 1985 Feb;32(1):127-33. doi: 10.1507/endocrj1954.32.127.
The effects of microelectrophoretic applications of neurotransmitter substances and their antagonists on the activity of paraventricular oxytocinergic neurones were studied in urethane anesthetized lactating rats. Oxytocinergic neurones were identified by their antidromic response to the stimulation of the neurohypophysis and by their characteristic high frequency discharge of action potentials approximately 15-20s before reflex milk ejection. Acetylcholine (ACh) excited the majority (75%) of paraventricular oxytocinergic neurones, and none of the cells was inhibited in its activity by ACh. In about half of the oxytocinergic cells, atropine and hexamethonium reduced the number of action potentials during the burst discharge preceding reflex milk ejection. Noradrenaline (NE), dopamine (DA) and serotonin (5-HT) reduced the activity of most (75-100%) of oxytocinergic neurones, and none of the cells was excited by these catecholamines. These results suggest that paraventricular oxytocinergic neurones receive excitatory cholinergic inputs and inhibitory noradrenergic, dopaminergic and serotonergic inputs.
在氨基甲酸乙酯麻醉的泌乳大鼠中，研究了微量电泳施加神经递质物质及其拮抗剂对室旁催产素能神经元活动的影响。催产素能神经元通过对神经垂体刺激的逆向反应以及在反射性乳汁喷射前约15 - 20秒其特征性的高频动作电位发放来识别。乙酰胆碱（ACh）兴奋了大多数（75%）的室旁催产素能神经元，且没有细胞的活动被ACh抑制。在大约一半的催产素能细胞中，阿托品和六甲铵减少了反射性乳汁喷射前爆发性放电期间的动作电位数量。去甲肾上腺素（NE）、多巴胺（DA）和5-羟色胺（5-HT）降低了大多数（75 - 100%）催产素能神经元的活动，且没有细胞被这些儿茶酚胺兴奋。这些结果表明，室旁催产素能神经元接受兴奋性胆碱能输入以及抑制性去甲肾上腺素能、多巴胺能和5-羟色胺能输入。
