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谷氨酰胺可改善鸭瘟病毒免疫反应引起的黏膜损伤。

Glutamine Ameliorates Mucosal Damage Caused by Immune Responses to Duck Plague Virus.

作者信息

Zhang Yuanyuan, Zhao Lili, Zhou Yan, Diao Chenxi, Han Lingxia, Yinjie Niu, Liu Shengwang, Chen Hongyan

机构信息

Heilongjiang Provincial Key Laboratory of Laboratory Animal and Comparative Medicine, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China.

Division of Avian Infectious Diseases, National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China.

出版信息

Dose Response. 2017 Jun 5;15(2):1559325817708674. doi: 10.1177/1559325817708674. eCollection 2017 Apr-Jun.

DOI:10.1177/1559325817708674
PMID:28620271
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5464388/
Abstract

The immune-releasing effects of L-glutamine (Gln) supplementation in duck plague virus (DPV)-infected ducklings were evaluated in 120 seven-day-old ducklings that were divided into 8 groups. The ducklings in control and DPV, 0.5Gln and DPV + 0.5Gln, 1.0Gln and DPV + 1.0Gln, and 2.0Gln and DPV + 2.0Gln received 0, 0.5, 1.0, and 2.0 g of Gln/kg feed/d by gastric perfusion, respectively. Then, the ducklings in control to 2.0Gln were injected with 0.2 mL of phosphate-buffered saline, while those in DPV to DPV + 2.0Gln were injected with DPV at 0.2 mL of 2000 TCID (50% tissue culture infection dose) 30 minutes after gavage with Gln, sampled at 12 hours and days 1, 2, 4, and 6. Glutamine supplementation under physiological conditions enhanced immune function and toll-like receptor 4 (TLR4) expressions in a dose-dependent manner. An increase in Gln supplementation under DPV-infected conditions enhanced growth performance, decreased immunoglobulin (Ig) release in plasma and secretory IgA in the duodenum, ameliorated plasma cytokine levels, and suppressed overexpressions of the TLR4 pathway in the duodenum. The positive effects of Gln on the humoral immunity- and intestinal inflammation-related damage should be considered a mechanism by which immunonutrition can assist in the recovery from DPV infection.

摘要

在120只7日龄雏鸭中评估了补充L-谷氨酰胺（Gln）对感染鸭瘟病毒（DPV）雏鸭的免疫释放作用，这些雏鸭被分为8组。对照组、DPV组、0.5Gln组和DPV + 0.5Gln组、1.0Gln组和DPV + 1.0Gln组、2.0Gln组和DPV + 2.0Gln组雏鸭分别通过胃灌注给予0、0.5、1.0和2.0 g Gln/kg饲料/天。然后，对照组至2.0Gln组雏鸭注射0.2 mL磷酸盐缓冲盐水，而DPV组至DPV + 2.0Gln组雏鸭在灌胃Gln 30分钟后注射0.2 mL含2000个TCID（50%组织培养感染剂量）的DPV，在12小时以及第1、2、4和6天进行采样。生理条件下补充谷氨酰胺以剂量依赖方式增强免疫功能和Toll样受体4（TLR4）表达。在感染DPV的条件下增加谷氨酰胺补充量可提高生长性能，降低血浆中免疫球蛋白（Ig）释放和十二指肠中分泌型IgA水平，改善血浆细胞因子水平，并抑制十二指肠中TLR4途径的过度表达。谷氨酰胺对体液免疫和肠道炎症相关损伤的积极作用应被视为免疫营养辅助从DPV感染中恢复的一种机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9604/5464388/f07b8385b54e/10.1177_1559325817708674-fig17.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9604/5464388/b6c85ff3961e/10.1177_1559325817708674-fig1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9604/5464388/b6c85ff3961e/10.1177_1559325817708674-fig1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9604/5464388/977061f86f40/10.1177_1559325817708674-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9604/5464388/9689aa5a6a1b/10.1177_1559325817708674-fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9604/5464388/ff56cba68631/10.1177_1559325817708674-fig9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9604/5464388/781222a4cd45/10.1177_1559325817708674-fig10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9604/5464388/069e73486f1b/10.1177_1559325817708674-fig11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9604/5464388/f65b8443473f/10.1177_1559325817708674-fig12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9604/5464388/c6daeaf51f19/10.1177_1559325817708674-fig13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9604/5464388/393a9c24b91b/10.1177_1559325817708674-fig14.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9604/5464388/8f23f88671b4/10.1177_1559325817708674-fig15.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9604/5464388/290effe7e145/10.1177_1559325817708674-fig16.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9604/5464388/f07b8385b54e/10.1177_1559325817708674-fig17.jpg

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