Watanabe K, Takeuchi H, Kurono M
Eur J Pharmacol. 1985 Apr 23;111(1):57-63. doi: 10.1016/0014-2999(85)90113-x.
The effects of four stereoisomers of beta-hydroxyglutamic acid (erythro-L-BHGA, threo-L-BHGA, erythro-D-BHGA and threo-D-BHGA) and glutamic acid (L-Glu and D-Glu) were compared on six identifiable giant neurons of Achatina fulica Férussac, namely, PON (periodically oscillating neuron), VIN (visceral intermittently firing neuron), d-RPLN (dorsal-right parietal large neuron), RAPN (right anterior pallial neuron), FAN (frequently autoactive neuron) and v-RCDN (ventral-right cerebral distinct neuron). On PON and VIN, erythro-L-BHGA was the most inhibitory (effective potency quotient (EPQ) of the substance: 1.0). Its minimum effective concentration (MEC) for both neurons was the same at 3 X 10(-5) M. The effect of threo-L-BHGA was weaker (EPQ in relation to the most effective substance: 0.3-0.1). Erythro- and threo-D-BHGAs were almost ineffective on PON (EPQ: less than 0.03) though they had some effects on VIN (EPQ: 0.1-0.03 for erythro-D-BHGA and 0.3-0.1 for threo-D-BHGA). On d-RPLN, erythro-L-BHGA was the most excitatory (MEC: 10(-4)M). Threo-L-BHGA and threo-D-BHGA also had some effects (EPQ: 0.1 and 0.3 respectively), while erythro-D-BHGA was ineffective. On RAPN, erythro- and threo-L-BHGAs were the most excitatory (MEC: 10(-4) M). Threo-D-BHGA was also excitatory (EPQ: 0.3), while erythro-D-BHGA was ineffective. Threo-L-BHGA was the most inhibitory on FAN and v-RCDN (MEC: 10(-4) M in FAN and 10(-5) M in v-RCDN).(ABSTRACT TRUNCATED AT 250 WORDS)
比较了β-羟基谷氨酸的四种立体异构体（赤藓糖型-L-BHGA、苏阿糖型-L-BHGA、赤藓糖型-D-BHGA和苏阿糖型-D-BHGA）以及谷氨酸（L-Glu和D-Glu）对非洲大蜗牛（Achatina fulica Férussac）的六个可识别的巨型神经元的作用，即周期性振荡神经元（PON）、内脏间歇性放电神经元（VIN）、背右侧顶叶大神经元（d-RPLN）、右前脑 pallial 神经元（RAPN）、频繁自发放电神经元（FAN）和腹右侧脑独特神经元（v-RCDN）。在PON和VIN上，赤藓糖型-L-BHGA的抑制作用最强（该物质的有效效价商（EPQ）：1.0）。这两种神经元的最小有效浓度（MEC）相同，均为3×10⁻⁵M。苏阿糖型-L-BHGA的作用较弱（相对于最有效物质的EPQ：0.3 - 0.1）。赤藓糖型和苏阿糖型-D-BHGAs对PON几乎无效（EPQ：小于0.03），尽管它们对VIN有一些作用（赤藓糖型-D-BHGA的EPQ：0.1 - 0.03，苏阿糖型-D-BHGA的EPQ：0.3 - 0.1）。在d-RPLN上，赤藓糖型-L-BHGA的兴奋作用最强（MEC：10⁻⁴M）。苏阿糖型-L-BHGA和苏阿糖型-D-BHGA也有一些作用（EPQ分别为0.1和0.3），而赤藓糖型-D-BHGA无效。在RAPN上，赤藓糖型和苏阿糖型-L-BHGAs的兴奋作用最强（MEC：10⁻⁴M）。苏阿糖型-D-BHGA也具有兴奋作用（EPQ：0.3），而赤藓糖型-D-BHGA无效。苏阿糖型-L-BHGA对FAN和v-RCDN的抑制作用最强（FAN的MEC：10⁻⁴M，v-RCDN的MEC：10⁻⁵M）。（摘要截取自250字）
