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复发性非小细胞肺癌的软脑膜癌病：一例报告及当前治疗方式综述

Leptomeningeal Carcinomatosis in Recurrent Non-Small Cell Lung Cancer: A Case Report and Review of Current Treatment Modalities.

作者信息

Abbasi Saqib, Moussaly Elias, Atallah Jean P

机构信息

Internal Medicine, Staten Island University Hospital.

Hematology / Oncology, Staten Island University Hospital.

出版信息

Cureus. 2017 May 12;9(5):e1242. doi: 10.7759/cureus.1242.

DOI:10.7759/cureus.1242
PMID:28620571
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5467982/
Abstract

Leptomeningeal carcinomatosis (LC) is an uncommon sequelae of non-small cell lung cancer. The treatment modalities for LC have historically been limited with an overall poor prognosis. This case report outlines a 76-year-old female who presented with recurrence of non-small cell lung cancer as LC. LC is difficult to treat, and options include radiation, chemotherapy (systemic and intrathecal), as well as targeted therapies. This case outlines a unique approach and reviews the current literature on the effectiveness of these options in non-small cell lung cancer.

摘要

软脑膜癌病（LC）是非小细胞肺癌一种不常见的后遗症。LC的治疗方式历来有限，总体预后较差。本病例报告概述了一名76岁女性，她因软脑膜癌病出现非小细胞肺癌复发。LC难以治疗，治疗选择包括放疗、化疗（全身和鞘内）以及靶向治疗。本病例概述了一种独特的方法，并回顾了当前关于这些治疗选择在非小细胞肺癌中有效性的文献。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e744/5467982/96af0131e67e/cureus-0009-00000001242-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e744/5467982/96af0131e67e/cureus-0009-00000001242-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e744/5467982/96af0131e67e/cureus-0009-00000001242-i01.jpg

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本文引用的文献

1
Alectinib in Crizotinib-Refractory ALK-Rearranged Non-Small-Cell Lung Cancer: A Phase II Global Study.克唑替尼治疗后进展的间变性淋巴瘤激酶阳性非小细胞肺癌患者中阿来替尼的疗效：一项全球 II 期研究。
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N Engl J Med. 2004 May 20;350(21):2129-39. doi: 10.1056/NEJMoa040938. Epub 2004 Apr 29.
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Randomized prospective comparison of intraventricular methotrexate and thiotepa in patients with previously untreated neoplastic meningitis. Eastern Cooperative Oncology Group.既往未经治疗的肿瘤性脑膜炎患者脑室内甲氨蝶呤与噻替派的随机前瞻性比较。东部肿瘤协作组。
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