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作为转录复制叉转移模式的DNA双组分模型中构象纽结的多重反射传播

Multireflection propagation of conformational kinks in a two-component model of DNA as the transfer mode of the transcriptional replication fork.

作者信息

Shikhovtseva E S, Nazarov V N

机构信息

Institute of Molecule and Crystal Physics Ufa Research Centre of Russian Academy of Sciences, Prospekt Oktyabrya 151, Ufa, 450075, Russia.

出版信息

Eur Biophys J. 2018 Jan;47(1):69-74. doi: 10.1007/s00249-017-1230-x. Epub 2017 Jun 15.

Abstract

The propagation, or movement, of a conformational kink along a linear structure can occur in capture, transfer, or multireflection modes. Here we use a model for two-component bistable polymer molecules with energetically non-equivalent stable states to model the propagation of the DNA transcription bubble via movement of a non-linear longitudinal stretching region along the DNA chain. We show that under certain conditions the longitudinal excitation can act as a reflector for a conformational kink and, furthermore, that conformational switching may propagate in a multireflection mode alongside conformational kink transition and conformational kink trapping.

摘要

构象扭结沿线性结构的传播或移动可以通过捕获、转移或多次反射模式发生。在此,我们使用具有能量不等价稳定态的双组分双稳态聚合物分子模型,通过非线性纵向拉伸区域沿DNA链的移动来模拟DNA转录泡的传播。我们表明,在某些条件下,纵向激发可以作为构象扭结的反射器,此外,构象转换可能会在多次反射模式下与构象扭结转变和构象扭结捕获一起传播。

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