肥大细胞在脑出血中的作用。
The Role of Mast Cells in Intracerebral Hemorrhage.
机构信息
Cerebrovascular and Neurocritical Care Division, Department of Neurology, Wexner Medical Center, The Ohio State University, 333 W. 10th Ave, Graves Hall, Rm. 3172, Columbus, OH, 43210, USA.
Department of Neurosurgery, Wexner Medical Center, The Ohio State University, Columbus, OH, USA.
出版信息
Neurocrit Care. 2018 Jun;28(3):288-295. doi: 10.1007/s12028-017-0416-5.
Abstract
Mast cells are first responders to intracerebral hemorrhage. They release potent mediators that can disrupt the blood-brain barrier promoting injury, vasogenic edema formation, and hematoma exacerbation. Also, mast cells recruit other inflammatory cells that maintain and amplify brain damage. Given their early role in the cascade of events in intracerebral hemorrhage, mast cells may offer an alternative target for antichemotactic interventions.
摘要
肥大细胞是脑出血的早期反应者。它们释放的有效介质可破坏血脑屏障，促进损伤、血管源性水肿形成和血肿恶化。此外，肥大细胞还招募其他炎症细胞，维持和放大脑损伤。鉴于它们在脑出血级联反应中的早期作用，肥大细胞可能为趋化因子干预提供另一种靶向治疗。
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本文引用的文献
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Secondary Hematoma Expansion and Perihemorrhagic Edema after Intracerebral Hemorrhage: From Bench Work to Practical Aspects.脑出血后的继发性血肿扩大及出血周围水肿：从基础研究到实际应用
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Intracerebral Hemorrhage: Perihemorrhagic Edema and Secondary Hematoma Expansion: From Bench Work to Ongoing Controversies.脑出血：出血周围水肿与继发性血肿扩大：从基础研究到持续争议
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Impact of Perihemorrhagic Edema on Short-Term Outcome After Intracerebral Hemorrhage.脑出血后出血周围水肿对短期预后的影响。
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