脑出血：出血周围水肿与继发性血肿扩大：从基础研究到持续争议
Intracerebral Hemorrhage: Perihemorrhagic Edema and Secondary Hematoma Expansion: From Bench Work to Ongoing Controversies.
作者信息
Mittal Manoj K, LacKamp Aaron
机构信息
Department of Neurology, University of Kansas Medical Center , Kansas City, KS , USA.
Department of Anesthesiology, University of Kansas Medical Center , Kansas City, KS , USA.
出版信息
Front Neurol. 2016 Nov 21;7:210. doi: 10.3389/fneur.2016.00210. eCollection 2016.
Abstract
Intracerebral hemorrhage (ICH) is a medical emergency, which often leads to severe disability and death. ICH-related poor outcomes are due to primary injury causing structural damage and mass effect and secondary injury in the perihemorrhagic region over several days to weeks. Secondary injury after ICH can be due to hematoma expansion (HE) or a consequence of repair pathway along the continuum of neuroinflammation, neuronal death, and perihemorrhagic edema (PHE). This review article is focused on PHE and HE and will cover the animal studies, related human studies, and clinical trials relating to these mechanisms of secondary brain injury in ICH patients.
摘要
脑出血（ICH）是一种医疗急症，常导致严重残疾和死亡。与ICH相关的不良后果是由于原发性损伤导致结构破坏和占位效应，以及在数天至数周内出血周围区域的继发性损伤。ICH后的继发性损伤可能是由于血肿扩大（HE）或沿着神经炎症、神经元死亡和出血周围水肿（PHE）连续过程的修复途径的结果。这篇综述文章聚焦于PHE和HE，并将涵盖与ICH患者继发性脑损伤这些机制相关的动物研究、相关人体研究和临床试验。
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本文引用的文献
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N Engl J Med. 2016 Sep 22;375(12):1131-41. doi: 10.1056/NEJMoa1607887. Epub 2016 Aug 30.
2
Prothrombin complex concentrates versus fresh frozen plasma for warfarin reversal. A systematic review and meta-analysis.凝血酶原复合物浓缩物与新鲜冷冻血浆在华法林逆转中的比较。系统评价和荟萃分析。
Thromb Haemost. 2016 Oct 28;116(5):879-890. doi: 10.1160/TH16-04-0266. Epub 2016 Aug 4.
3
Intracerebral Hematoma Occurring During Warfarin Versus Non-Vitamin K Antagonist Oral Anticoagulant Therapy.华法林与非维生素K拮抗剂口服抗凝治疗期间发生的颅内血肿
Am J Cardiol. 2016 Jul 15;118(2):222-5. doi: 10.1016/j.amjcard.2016.04.034. Epub 2016 May 5.
4
Intensive Blood-Pressure Lowering in Patients with Acute Cerebral Hemorrhage.急性脑出血患者的强化血压降低
N Engl J Med. 2016 Sep 15;375(11):1033-43. doi: 10.1056/NEJMoa1603460. Epub 2016 Jun 8.
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Lancet. 2016 Jun 25;387(10038):2605-2613. doi: 10.1016/S0140-6736(16)30392-0. Epub 2016 May 10.
6
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Malays J Med Sci. 2015 Dec;22(Spec Issue):62-71.
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