Srinivas Avula, Sunitha Malladi, Raju Kammachichu, Ravinder Banothu, Anusha Siluveru, Rajasri Thallapalli, Swapna Pothuganti, Sushmitha Dupa, Swaroopa Deva, Nikitha Gurala, Rao Chakunta
Acta Chim Slov. 2017 Jun;64(2):319-331. doi: 10.17344/acsi.2016.3153.
In a one pot procedure, a series of novel hybrid heterocycles 6a-g and 7a-g were prepared by condensation of (3aS,4S,6S,6aS)-6-((1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)methoxy)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole-4-carbaldehyde 5 with mercapto acids and primary amines in the presence of ZnCl2 under both microwave irradiation and conventional heating conditions. Compound 5 was prepared from di-acetone D-mannose via a click reaction, primary acetonide deprotection and oxidative cleavage. Characterization of new compounds has been done by IR, NMR, MS and elemental analysis. Anticancer activity of the compounds has also been evaluated.
在一锅法中，在微波辐射和常规加热条件下，以（3aS，4S，6S，6aS）-6-（（1-（4-氯苯基）-1H-1,2,3-三唑-4-基）甲氧基）-2,2-二甲基四氢呋喃并[3,4-d][1,3]二氧杂环戊烯-4-甲醛5与巯基酸和伯胺在氯化锌存在下缩合，制备了一系列新型杂化杂环化合物6a - g和7a - g。化合物5由双丙酮D-甘露糖通过点击反应、原丙酮化物脱保护和氧化裂解制备。通过红外光谱、核磁共振、质谱和元素分析对新化合物进行了表征。还评估了这些化合物的抗癌活性。
