镓标记的AGuIX纳米颗粒作为用于PET/MRI引导放射治疗的双模态成像剂。

Ga-radiolabeled AGuIX nanoparticles as dual-modality imaging agents for PET/MRI-guided radiation therapy.

作者信息

Bouziotis Penelope, Stellas Dimitris, Thomas Eloïse, Truillet Charles, Tsoukalas Charalampos, Lux François, Tsotakos Theodoros, Xanthopoulos Stavros, Paravatou-Petsotas Maria, Gaitanis Anastasios, Moulopoulos Lia Angela, Koutoulidis Vassilis, Anagnostopoulos Constantinos D, Tillement Olivier

机构信息

Institute of Nuclear & Radiological Sciences & Technology, Energy & Safety, National Center for Scientific Research 'Demokritos,' Aghia Paraskevi 15310, Athens, Greece.

Biomedical Research Foundation of the Academy of Athens, 4 Soranou Ephessiou Street, 11527, Athens, Greece.

出版信息

Nanomedicine (Lond). 2017 Jul;12(13):1561-1574. doi: 10.2217/nnm-2017-0032. Epub 2017 Jun 16.

DOI:10.2217/nnm-2017-0032

PMID:28621567

Abstract

AIM

The aim of this study was to develop a dual-modality positron emission tomography/magnetic resonance (PET/MR) imaging probe by radiolabeling gadolinium-containing AGuIX derivatives with the positron-emitter Gallium-68 (Ga).

MATERIALS & METHODS: AGuIX@NODAGA nanoparticles were labeled with Ga at high efficiency. Tumor accumulation in an appropriate disease model was assessed by ex vivo biodistribution and in vivo PET/MR imaging.

RESULTS

Ga-AGuIX@NODAGA was proven to passively accumulate in U87MG human glioblastoma tumor xenografts. Metabolite assessment in serum, urine and tumor samples showed that Ga-AGuIX@NODAGA remains unmetabolized up to at least 60 min postinjection.

CONCLUSION

This study demonstrates that Ga-AGuIX@NODAGA can be used as a dual-modality PET/MR imaging agent with passive accumulation in the diseased area, thus showing great potential for PET/MR image-guided radiation therapy.

摘要