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用于PET/MRI/光学成像的诊疗一体化AGuIX®纳米颗粒的功能化

Functionalization of theranostic AGuIX® nanoparticles for PET/MRI/optical imaging.

作者信息

Thakare Vivek, Tran Vu-Long, Natuzzi Marco, Thomas Eloïse, Moreau Mathieu, Romieu Anthony, Collin Bertrand, Courteau Alan, Vrigneaud Jean-Marc, Louis Cédric, Roux Stéphane, Boschetti Frédéric, Tillement Olivier, Lux François, Denat Franck

机构信息

Institut de Chimie Moléculaire de l'Université de Bourg, UMR 6302, CNRS, Université Bourgogne Franche-Comté 9 Avenue Alain Savary 21000 Dijon France

CheMatech 2 rue Pauline Kergomard 21000 Dijon France.

出版信息

RSC Adv. 2019 Aug 9;9(43):24811-24815. doi: 10.1039/c9ra00365g. eCollection 2019 Aug 8.

DOI:10.1039/c9ra00365g
PMID:35528689
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9073358/
Abstract

A novel trifunctional imaging probe containing a chelator of radiometal for PET, a NIR heptamethine cyanine dye, and a bioconjugatable handle, has been grafted onto AGuIX® nanoparticles a Michael addition reaction. The resulting functionalized nanoparticles have been fully characterized, radiolabelled with Cu, and evaluated in a mice TSA tumor model using multimodal (PET/MRI/optical) imaging.

摘要

一种新型三功能成像探针，包含用于正电子发射断层扫描（PET）的放射性金属螯合剂、近红外七甲川花菁染料和可生物共轭的手柄，已通过迈克尔加成反应接枝到AGuIX®纳米颗粒上。所得功能化纳米颗粒已得到充分表征，用铜进行放射性标记，并在小鼠TSA肿瘤模型中使用多模态（PET/MRI/光学）成像进行评估。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/802e/9073358/59c84468505b/c9ra00365g-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/802e/9073358/4459b28205a6/c9ra00365g-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/802e/9073358/a088fd50c65e/c9ra00365g-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/802e/9073358/f2669377fe80/c9ra00365g-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/802e/9073358/59c84468505b/c9ra00365g-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/802e/9073358/4459b28205a6/c9ra00365g-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/802e/9073358/a088fd50c65e/c9ra00365g-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/802e/9073358/f2669377fe80/c9ra00365g-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/802e/9073358/59c84468505b/c9ra00365g-f4.jpg

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