Spector S L
J Allergy Clin Immunol. 1985 Aug;76(2 Pt 2):302-11. doi: 10.1016/0091-6749(85)90646-3.
The general trend in medical therapy toward once-daily administration has not escaped theophylline preparations. Rapid metabolizers, as are found especially among children and smoking adults, may require a more frequent interval than once-a-day dosing, and greater fluctuations in theophylline levels should be expected. An interaction with food has been seen with once- and twice-daily theophylline preparations. Some products release their contents more rapidly while others do so more slowly in association with a high-fat diet. The food effect is of little concern if the theophylline is taken 1 hour before the meal. The greatest anticipated value of once-daily theophylline medications would be improved patient compliance.
每日一次给药的医学治疗总体趋势也适用于茶碱制剂。快速代谢者，尤其在儿童和吸烟成年人中较为常见，可能需要比每日一次给药更频繁的间隔时间，并且茶碱水平的波动会更大。每日一次和每日两次的茶碱制剂都存在与食物的相互作用。一些产品在高脂饮食的情况下，其内容物释放更快，而另一些则更慢。如果在饭前1小时服用茶碱，则食物效应几乎无需担忧。每日一次的茶碱药物最大的预期价值在于提高患者的依从性。
