钌催化的2-吡啶酮和1-异喹啉酮的位点选择性C-H芳基化反应。

Ruthenium-catalyzed site-selective C-H arylation of 2-pyridones and 1-isoquinolinones.

作者信息

Anil Kumar K, Kannaboina Prakash, Das Parthasarathi

机构信息

Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Jammu 180001, India.

出版信息

Org Biomol Chem. 2017 Jul 5;15(26):5457-5461. doi: 10.1039/c7ob01277b.

DOI:10.1039/c7ob01277b

PMID:28621792

Abstract

An efficient Ru(ii)-catalyzed site-selective C-H arylation of 2-pyridones and 1-isoquinolinones was achieved with boronic acids by using pyridine as a directing group. The developed protocol is general and provides rapid access to an array of C6-arylated 2-pyridones and C3-arylated 1-isoquinolinones in excellent yields. These designed arylated 2-pyridones and 1-isoquinolinones can serve as key structural motifs for accessing functionalized pyridines and isoquinolines.

摘要

通过使用吡啶作为导向基团，实现了一种高效的钌（II）催化的2-吡啶酮和1-异喹啉酮与硼酸的位点选择性C-H芳基化反应。所开发的方法具有通用性，能够以优异的产率快速获得一系列C6-芳基化的2-吡啶酮和C3-芳基化的1-异喹啉酮。这些设计的芳基化2-吡啶酮和1-异喹啉酮可作为获取功能化吡啶和异喹啉的关键结构基序。