Hirano Koji, Miura Masahiro
Department of Applied Chemistry , Graduate School of Engineering , Osaka University , Suita , Osaka 565-0871 , Japan . Email:
Chem Sci. 2017 Nov 27;9(1):22-32. doi: 10.1039/c7sc04509c. eCollection 2018 Jan 7.
A 2-pyridone ring is a frequently occurring subunit in natural products, biologically active compounds, and pharmaceutical targets. Thus, the selective synthesis of substituted 2-pyridone derivatives through decoration and/or formation of pyridone rings has been one of the important longstanding subjects in organic synthetic chemistry. This minireview focuses on recent advances in site-selective C-H functionalization on 2-pyridone. The reported procedures are categorized according to the site selectivity that is achieved, and the substrate scope, limitations, mechanism, and controlling factors are briefly summarized.
2-吡啶酮环是天然产物、生物活性化合物和药物靶点中常见的亚基。因此，通过吡啶酮环的修饰和/或形成来选择性合成取代的2-吡啶酮衍生物一直是有机合成化学中重要的长期研究课题之一。本综述聚焦于2-吡啶酮位点选择性C-H官能化的最新进展。所报道的方法根据实现的位点选择性进行分类，并简要总结了底物范围、局限性、机理和控制因素。
