Cao Danh H, Strolin Benedetti M, Mousset A, Pasquier-Béchet P
J Pharm Pharmacol. 1985 May;37(5):357-61. doi: 10.1111/j.2042-7158.1985.tb05084.x.
Eye MAO-A, MAO-B, semicarbazide-sensitive amine oxidase (SSAO) and aldehyde reductase (AR) activities were measured in young and old rats. When enzyme activity is expressed as nmol (mg protein)-1 min-1, a significant decrease (18-23%) of SSAO activity in the eye of old rats was found, whereas there was no significant difference in MAO-A and MAO-B activities. A significant increase of AR activity with D-xylose (67%), DL-glyceraldehyde (64%), D-glucuronate (43%) and D-glucose (21%) was found in the eye of old rats. These results suggest that changes in the activities of the amine metabolizing enzymes of rat eye with age might have consequences for their function in senescence; particularly, the increase of AR activity might be involved in cataract formation.
在年轻和老年大鼠中测量了眼部单胺氧化酶A（MAO-A）、单胺氧化酶B（MAO-B）、氨基脲敏感胺氧化酶（SSAO）和醛还原酶（AR）的活性。当酶活性以nmol（mg蛋白质）-1分钟-1表示时，发现老年大鼠眼部的SSAO活性显著降低（18-23%），而MAO-A和MAO-B活性没有显著差异。在老年大鼠的眼中发现，AR活性随着D-木糖（67%）、DL-甘油醛（64%）、D-葡萄糖醛酸（43%）和D-葡萄糖（21%）显著增加。这些结果表明，大鼠眼部胺代谢酶活性随年龄的变化可能会对其在衰老过程中的功能产生影响；特别是，AR活性的增加可能与白内障的形成有关。
