Kanatani H, Kohda H, Yamasaki K, Hotta I, Nakata Y, Segawa T, Yamanaka E, Aimi N, Sakai S
J Pharm Pharmacol. 1985 Jun;37(6):401-4. doi: 10.1111/j.2042-7158.1985.tb03023.x.
Of the alkaloids obtained from Uncaria sinensis Oliv., geissoschizine methyl ether, corynantheine and dihydrocorynantheine decreased specific [3H]5-HT binding to membrane preparations from rat brain and from in-vitro experiments on guinea-pig ileum, these alkaloids were found to be partial agonists for 5-HT receptors. Therefore, they might be useful in the treatment of diseases resulting from disorders of 5-HT metabolism.
从中华钩藤中获得的生物碱中，盖斯索奇辛甲基醚、可立南辛和二氢可立南辛降低了大鼠脑细胞膜制剂与[3H]5-羟色胺的特异性结合，并且在豚鼠回肠的体外实验中，这些生物碱被发现是5-羟色胺受体的部分激动剂。因此，它们可能有助于治疗由5-羟色胺代谢紊乱引起的疾病。
