Mundis Gregory M, Turner Jay D, Deverin Vedat, Uribe Juan S, Nunley Pierce, Mummaneni Praveen, Anand Neel, Park Paul, Okonkwo David O, Wang Michael Y, Bess Shay, Kanter Adam S, Fessler Richard, Nguyen Stacie, Akbarnia Behrooz A
San Diego Spine Foundation, 6190 Cornerstone Ct. Suite 212, San Diego, CA 92121, USA; Scripps Clinic, 10666 N Torrey Pines Rd., La Jolla, CA 92036, USA.
San Diego Spine Foundation, 6190 Cornerstone Ct. Suite 212, San Diego, CA 92121, USA; Barrow Neurological Institute, 350 W Thomas Rd., Phoenix, AZ 85013, USA.
Spine Deform. 2017 Jul;5(4):265-271. doi: 10.1016/j.jspd.2017.01.010.
Sagittal plane realignment is important to achieve desirable clinical outcomes after adult spinal deformity (ASD) surgery. This study evaluates the impact of minimally invasive (MIS) techniques on sagittal plane alignment and clinical outcomes in ASD patients.
A retrospective, multi-center review of ASD patients (age ≥18 years, and with one of the following: coronal Cobb ≥20°, sagittal vertical axis [SVA] >5 cm, and/or pelvic tilt >25°), MIS surgery, and four or more levels instrumented. Patients were stratified by baseline SRS-Schwab global alignment modifier (GAM) into three groups: 0 (SVA <4 cm), + (SVA 4-9.5 cm), or ++ (SVA >9.5 cm). Radiographic and clinical outcomes measures were analyzed with a minimum of 2-year follow-up.
A total of 96 ASD patients were identified, and 63 met the study's inclusion criteria of circumferential MIS or posterior MIS only, with four or more levels instrumented (n: Group 0 = 37, Group + = 15, and Group ++ = 11). Group 0 was younger than ++ (56.8 vs. 69.6 years), with a higher proportion of females than Group + or ++ (83.8% vs. 66.7% and 54.5%, respectively). Baseline HRQoL was similar. Postoperatively, Groups 0 and + had improved Oswestry Disability Index (ODI) and numeric rating scale (NRS) back and leg scores. Group ++ only had improvement in NRS scores. At the latest follow-up, Groups 0 and ++ had similar sagittal measurements except for PT (21.6 vs. 23.6, p = .009). The + group had improvement in PI-LL (24.2 to 17; p = .015) and LL (30.9 to 38.3; p = .013). Eight of 27 (21.6%) Group 0 patients deteriorated (4 to Group +, 4 to Group ++). Three of 15 (20.0%) Group + patients deteriorated to Group ++, and 3 improved to Group 0. Six of 11 (54.5%) Group ++ patients improved (3 to Group + and 3 to Group 0).
MIS techniques successfully stabilized ASD patients with Group 0 and + deformities and improved HRQoL. This study suggests that severe sagittal imbalance is not adequately treated with MIS approaches.
矢状面重新排列对于成人脊柱畸形(ASD)手术后获得理想的临床效果很重要。本研究评估了微创(MIS)技术对ASD患者矢状面排列和临床结果的影响。
对ASD患者(年龄≥18岁,且具备以下之一:冠状面Cobb角≥20°、矢状垂直轴[SVA]>5 cm和/或骨盆倾斜>25°)、MIS手术以及四个或更多节段进行器械固定的患者进行回顾性多中心研究。患者根据基线SRS-Schwab整体排列修正值(GAM)分为三组:0组(SVA<4 cm)、+组(SVA 4 - 9.5 cm)或++组(SVA>9.5 cm)。对影像学和临床结果指标进行分析,随访时间至少为2年。
共确定96例ASD患者,63例符合仅行环形MIS或后路MIS且四个或更多节段进行器械固定的研究纳入标准(n:0组 = 37例,+组 = 15例,++组 = 11例)。0组比++组年轻(56.8岁对69.6岁),女性比例高于+组或++组(分别为83.8%对66.7%和54.5%)。基线健康相关生活质量相似。术后,0组和+组的Oswestry功能障碍指数(ODI)以及数字评分量表(NRS)背部和腿部评分有所改善。++组仅NRS评分有所改善。在最近一次随访时,0组和++组的矢状面测量值相似,但骨盆倾斜度(PT)除外(21.6对23.6,p = 0.009)。+组的骨盆入射角 - 腰椎前凸角(PI-LL)(从24.2改善至17;p = 0.015)和腰椎前凸角(LL)(从30.9改善至38.3;p = 0.013)有所改善。27例0组患者中有8例(21.6%)病情恶化(4例变为+组,4例变为++组)。15例+组患者中有3例(20.0%)病情恶化为++组,3例改善为0组。11例++组患者中有6例(54.5%)病情改善(3例变为+组,3例变为0组)。
MIS技术成功地稳定了0组和+组畸形的ASD患者,并改善了健康相关生活质量。本研究表明,MIS方法对严重矢状面失衡的治疗效果不佳。