Cosio F G, Zager R A, Sharma H M
Lancet. 1985 Jul 20;2(8447):118-21. doi: 10.1016/s0140-6736(85)90225-9.
7 patients with atheroembolic renal disease were found to have hypocomplementaemia. Evidence obtained in an experimental model of atheroembolic disease shows that the hypocomplementaemia is the result of complement activation by the atheromatous material in vivo. In addition to hypocomplementaemia, 6 patients had thrombocytopenia and 5 had eosinophilia. These observations indicate that atheroembolic disease should now be included in the differential diagnosis of hypocomplementaemia. In addition, atheroembolic disease should be considered in patients presenting with a combination of multisystem disease, hypocomplementaemia, thrombocytopenia, and eosinophilia--a syndrome which previously would have been regarded as diagnostic of immune-complex-mediated vasculitis.
7例动脉粥样硬化栓塞性肾病患者被发现有补体减少。在动脉粥样硬化栓塞性疾病的实验模型中获得的证据表明，补体减少是体内动脉粥样硬化物质激活补体的结果。除补体减少外，6例患者有血小板减少，5例有嗜酸性粒细胞增多。这些观察结果表明，动脉粥样硬化栓塞性疾病现在应纳入补体减少的鉴别诊断中。此外，对于出现多系统疾病、补体减少、血小板减少和嗜酸性粒细胞增多组合的患者，应考虑动脉粥样硬化栓塞性疾病——一种以前会被视为免疫复合物介导的血管炎诊断依据的综合征。
